Ovulation induction/intrauterine insemination in infertile couples is associated with low-birth-weight infants

Gaudoin, Marco, Dobbie, Richard, Finlayson, Alan, Chalmers, James, Cameron, Iain T. and Fleming, Richard (2003) Ovulation induction/intrauterine insemination in infertile couples is associated with low-birth-weight infants. American Journal of Obstetrics and Gynecology, 188, (3), 611-616. (doi:10.1067/mob.2003.5).


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Original Publication URL: http://dx.doi.org/10.1067/mob.2003.5


Objective: The study was undertaken to determine the outcome of singleton pregnancies conceived through ovulation induction and intrauterine insemination using a partner's (OI/IUI) or donor sperm (OI/IUID) by comparison with naturally conceived singletons within a national cohort.

Study Design: Retrospective cohort study in primigravid women who were treated with OI/IUI (n = 97) or OI/IUID (n = 35) at Glasgow Royal Infirmary between March 1993 and March 1997 and identified within the Scottish national cohort (n = 109,443) delivering during the same period. Univariate and multivariate logistic regression models were used to examine outcomes and to determine the factors associated with infertility treatment and low birth weight.

Results: OI/IUI singletons were more likely to be lighter, of clinically low birth weight, and born more prematurely than natural conceptions. After adjustment for associated factors, these infants were 4.85 times (95% CI 2.25-10.48) more likely to be of low birth weight. We could not demonstrate any differences between OI/IUID and natural conceptions.

Conclusion: The perinatal outcome of singletons born to subfertile mothers conceived through OI/IUI is poorer than that of matched natural conceptions. We suggest that intrinsic factors in subfertile couples predispose them to having smaller infants and that "infertility" should be added to the list of recognized factors associated with low birth weight.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1067/mob.2003.5
ISSNs: 0002-9378 (print)
Related URLs:
Subjects: R Medicine > RG Gynecology and obstetrics
Divisions : University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 25527
Accepted Date and Publication Date:
March 2003Published
Date Deposited: 11 Apr 2006
Last Modified: 31 Mar 2016 11:47
URI: http://eprints.soton.ac.uk/id/eprint/25527

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