The developmental origins of the metabolic syndrome

Gluckman, Peter D. and Hanson, Mark A. (2004) The developmental origins of the metabolic syndrome. Trends in Endocrinology and Metabolism, 15, (4), 183-187. (doi:10.1016/j.tem.2004.03.002).


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Both epidemiological and clinical evidence suggest relationships between the antenatal environment and the risk of developing insulin resistance and associated cardiovascular disease (part of the metabolic syndrome) in middle age. However, interpretation of these findings has been controversial. Recent experimental observations provide considerable evidence for a causal model linking adaptive responses to early environmental cues and the later risk of disease. Evolutionary and life history theory provide possible explanations of why these phenomena have persisted and how they might cause disease. In this article, we review the clinical and experimental perspectives on the ‘developmental origins of disease’ model in the context of these new concepts.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/j.tem.2004.03.002
ISSNs: 1043-2760 (print)
Related URLs:
Subjects: R Medicine > RG Gynecology and obstetrics
Divisions : University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 25542
Accepted Date and Publication Date:
Date Deposited: 07 Apr 2006
Last Modified: 31 Mar 2016 11:47

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