The developmental origins of adult disease


Gluckman, Peter D., Hanson, Mark A. and Pinal, Catherine (2005) The developmental origins of adult disease. Maternal and Child Nutrition, 1, (3), 130-141. (doi:10.1111/j.1740-8709.2005.00020.x).

Download

Full text not available from this repository.

Description/Abstract

Epidemiological and clinical observations have led to the hypothesis that the risk of developing some chronic diseases in adulthood is influenced not only by genetic and adult lifestyle factors, but also by environmental factors acting in early life. These factors act through the processes of developmental plasticity and possibly epigenetic modification, and can be distinguished from developmental disruption. The concept of predictive adaptation has been developed to explain the relationship between early life events and the risk of later disease. At its base, the model suggests that a mismatch between fetal expectation of its postnatal environment and actual postnatal environment contribute to later adult disease risk. This mismatch is exacerbated, in part, by the phenomenon of 'maternal constraint' on fetal growth, which implicitly provides an upper limit of postnatal nutritional environment that humans have adapted for and is now frequently exceeded. These experimental, clinical and conceptual considerations have important implications for prevention and intervention in the current epidemic of childhood obesity and adult metabolic and cardiovascular disorders.

Item Type: Article
ISSNs: 1740-8695 (print)
Related URLs:
Keywords: predictive adaptive response, evolution, metabolic, fetal growth, developmental plasticity
Subjects: R Medicine > RG Gynecology and obstetrics
Divisions: University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 25545
Date Deposited: 07 Apr 2006
Last Modified: 27 Mar 2014 18:14
URI: http://eprints.soton.ac.uk/id/eprint/25545

Actions (login required)

View Item View Item