Relation between size at birth and age-related cataract
Relation between size at birth and age-related cataract
PURPOSE. To determine whether poor fetal growth, as determined by size at birth, is associated with an increased risk of age-related cataract.
METHODS. A total of 741 men and women born in Sheffield, England between 1922 and 1930 and whose size at birth was available were traced and invited to take part in the study. Of these, 392 (53%) attended for ophthalmic examination. Lens opacity in these volunteers was graded using the Lens Opacities Classification System (LOCS) III.
RESULTS. After adjusting for age, gender, gestational age, and risk factors for cataract there were no consistent associations between size at birth and age-related cataract. However, the odds ratio for nuclear cataract (opalescence) among subjects whose birth weight was more than 8 lb was 2.4 (95% CI 1.2 to 5.0) compared with those who weighed under 6 lb 12 oz at birth. Risk of cortical cataract by contrast fell with increasing birth weight, but the trend was not significant and became weak after adjusting for gestational age and other risk factors for cataract. No relation was evident between risk of posterior subcapsular cataract and size at birth.
CONCLUSIONS. There is no consistent association between size at birth and age-related cataract. The higher risk of nuclear cataract with increased birth weight was contrary to the expected trend. The apparent difference in direction of the relation between birth weight and different subtypes of cataract may be a chance finding but warrants further exploration.
614-619
Hall, Nigel F.
cd32d48e-a60b-4a7e-b1a2-99cfb8c68c58
Gale, Catharine R.
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Syddall, Holly E.
a0181a93-8fc3-4998-a996-7963f0128328
Martyn, Christpher N.
f687a4b6-b4eb-4b86-96e6-540ed69a7a27
Phillips, David I.W.
29b73be7-2ff9-4fff-ae42-d59842df4cc6
2001
Hall, Nigel F.
cd32d48e-a60b-4a7e-b1a2-99cfb8c68c58
Gale, Catharine R.
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Syddall, Holly E.
a0181a93-8fc3-4998-a996-7963f0128328
Martyn, Christpher N.
f687a4b6-b4eb-4b86-96e6-540ed69a7a27
Phillips, David I.W.
29b73be7-2ff9-4fff-ae42-d59842df4cc6
Hall, Nigel F., Gale, Catharine R., Syddall, Holly E., Martyn, Christpher N. and Phillips, David I.W.
(2001)
Relation between size at birth and age-related cataract.
Investigative Ophthalmology & Visual Science, 42 (3), .
Abstract
PURPOSE. To determine whether poor fetal growth, as determined by size at birth, is associated with an increased risk of age-related cataract.
METHODS. A total of 741 men and women born in Sheffield, England between 1922 and 1930 and whose size at birth was available were traced and invited to take part in the study. Of these, 392 (53%) attended for ophthalmic examination. Lens opacity in these volunteers was graded using the Lens Opacities Classification System (LOCS) III.
RESULTS. After adjusting for age, gender, gestational age, and risk factors for cataract there were no consistent associations between size at birth and age-related cataract. However, the odds ratio for nuclear cataract (opalescence) among subjects whose birth weight was more than 8 lb was 2.4 (95% CI 1.2 to 5.0) compared with those who weighed under 6 lb 12 oz at birth. Risk of cortical cataract by contrast fell with increasing birth weight, but the trend was not significant and became weak after adjusting for gestational age and other risk factors for cataract. No relation was evident between risk of posterior subcapsular cataract and size at birth.
CONCLUSIONS. There is no consistent association between size at birth and age-related cataract. The higher risk of nuclear cataract with increased birth weight was contrary to the expected trend. The apparent difference in direction of the relation between birth weight and different subtypes of cataract may be a chance finding but warrants further exploration.
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Published date: 2001
Organisations:
Dev Origins of Health & Disease
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Local EPrints ID: 25577
URI: http://eprints.soton.ac.uk/id/eprint/25577
ISSN: 0146-0404
PURE UUID: 80e656c4-3278-4cff-a23c-c4955634eed0
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Date deposited: 19 Apr 2006
Last modified: 09 Jan 2022 02:56
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Author:
Nigel F. Hall
Author:
Christpher N. Martyn
Author:
David I.W. Phillips
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