Serum insulin-like growth factor-I concentrations in late middle age: no association with birthweight in three UK cohorts


Holt, R.I.G., Syddall, H.E., Phillips, D.I.W., Martyn, C.N., Gluckman, P.D., Breier, B.H., Wood, P.J. and Fall, C.H. (2004) Serum insulin-like growth factor-I concentrations in late middle age: no association with birthweight in three UK cohorts. Acta Physiologica Scandinavica, 180, (4), 359-366. (doi:10.1111/j.1365-201X.2004.01262.x).

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Description/Abstract

Background:
Small body size at birth and during infancy is associated with an increased risk of adult osteoporosis and cardiovascular disease. Fetal programming of the growth hormone–insulin-like growth factor (GH-IGF) axis may provide a mechanism for these epidemiological findings.

Aims:
To determine whether measurements of GH and IGF-I in late middle age were related to size at birth and in infancy.

Methods:
Overnight urinary GH excretion and fasting serum IGF-I were measured in 309 men and 193 women from Hertfordshire (born 1920–1930) for whom birthweight and weight at 1 year were recorded. Serum IGF-I was measured in men and women from Preston (n = 254, born 1935–1943) and Sheffield (n = 215, born 1939–1940) whose birthweight and other birth measurements were recorded.

Results:
Urinary GH and serum IGF-I were not related to birthweight, other measurements at birth, or weight at 1 year.

Conclusion:
In contrast to previous studies in children or young adults, these data do not support the hypothesis that IGF-I concentrations are programmed by intra-uterine events, as assessed by birthweight, in late middle age.

Item Type: Article
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Keywords: adult height, birthweight, growth hormone, insulin-like growth factor-i, infancycardiovascular risk-factors, impaired glucose-tolerance, hormone-secretion, adult life, binding-proteins, heart-disease, fetal-growth, elderly-men, igf-i, women
Subjects: Q Science > QP Physiology
Q Science > QH Natural history > QH426 Genetics
R Medicine > RJ Pediatrics
Divisions: University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
University Structure - Pre August 2011 > School of Chemistry
University Structure - Pre August 2011 > School of Medicine > Human Genetics
ePrint ID: 25630
Date Deposited: 11 Apr 2006
Last Modified: 27 Mar 2014 18:14
Contact Email Address: R.I.G.Holt@soton.ac.uk
URI: http://eprints.soton.ac.uk/id/eprint/25630

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