Serum insulin-like growth factor-I concentrations in late middle age: no association with birthweight in three UK cohorts
Holt, R.I.G., Syddall, H.E., Phillips, D.I.W., Martyn, C.N., Gluckman, P.D., Breier, B.H., Wood, P.J. and Fall, C.H. (2004) Serum insulin-like growth factor-I concentrations in late middle age: no association with birthweight in three UK cohorts. Acta Physiologica Scandinavica, 180, (4), 359-366. (doi:10.1111/j.1365-201X.2004.01262.x).
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Small body size at birth and during infancy is associated with an increased risk of adult osteoporosis and cardiovascular disease. Fetal programming of the growth hormone–insulin-like growth factor (GH-IGF) axis may provide a mechanism for these epidemiological findings.
To determine whether measurements of GH and IGF-I in late middle age were related to size at birth and in infancy.
Overnight urinary GH excretion and fasting serum IGF-I were measured in 309 men and 193 women from Hertfordshire (born 1920–1930) for whom birthweight and weight at 1 year were recorded. Serum IGF-I was measured in men and women from Preston (n = 254, born 1935–1943) and Sheffield (n = 215, born 1939–1940) whose birthweight and other birth measurements were recorded.
Urinary GH and serum IGF-I were not related to birthweight, other measurements at birth, or weight at 1 year.
In contrast to previous studies in children or young adults, these data do not support the hypothesis that IGF-I concentrations are programmed by intra-uterine events, as assessed by birthweight, in late middle age.
|Keywords:||adult height, birthweight, growth hormone, insulin-like growth factor-i, infancycardiovascular risk-factors, impaired glucose-tolerance, hormone-secretion, adult life, binding-proteins, heart-disease, fetal-growth, elderly-men, igf-i, women|
|Subjects:||Q Science > QP Physiology
Q Science > QH Natural history > QH426 Genetics
R Medicine > RJ Pediatrics
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
University Structure - Pre August 2011 > School of Chemistry
University Structure - Pre August 2011 > School of Medicine > Human Genetics
|Date Deposited:||11 Apr 2006|
|Last Modified:||01 Apr 2012 02:20|
|Contributors:||Holt, R.I.G. (Author)
Syddall, H.E. (Author)
Phillips, D.I.W. (Author)
Martyn, C.N. (Author)
Gluckman, P.D. (Author)
Breier, B.H. (Author)
Wood, P.J. (Author)
Fall, C.H. (Author)
|Contact Email Address:||R.I.G.Holt@soton.ac.uk|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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