Serum insulin-like growth factor-I concentrations in late middle age: no association with birthweight in three UK cohorts
Holt, R.I.G., Syddall, H.E., Phillips, D.I.W., Martyn, C.N., Gluckman, P.D., Breier, B.H., Wood, P.J. and Fall, C.H. (2004) Serum insulin-like growth factor-I concentrations in late middle age: no association with birthweight in three UK cohorts. Acta Physiologica Scandinavica, 180, (4), 359-366. (doi:10.1111/j.1365-201X.2004.01262.x).
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Description/Abstract
Background:
Small body size at birth and during infancy is associated with an increased risk of adult osteoporosis and cardiovascular disease. Fetal programming of the growth hormone–insulin-like growth factor (GH-IGF) axis may provide a mechanism for these epidemiological findings.
Aims:
To determine whether measurements of GH and IGF-I in late middle age were related to size at birth and in infancy.
Methods:
Overnight urinary GH excretion and fasting serum IGF-I were measured in 309 men and 193 women from Hertfordshire (born 1920–1930) for whom birthweight and weight at 1 year were recorded. Serum IGF-I was measured in men and women from Preston (n = 254, born 1935–1943) and Sheffield (n = 215, born 1939–1940) whose birthweight and other birth measurements were recorded.
Results:
Urinary GH and serum IGF-I were not related to birthweight, other measurements at birth, or weight at 1 year.
Conclusion:
In contrast to previous studies in children or young adults, these data do not support the hypothesis that IGF-I concentrations are programmed by intra-uterine events, as assessed by birthweight, in late middle age.
| Item Type: | Article |
|---|---|
| Related URLs: | |
| Keywords: | adult height, birthweight, growth hormone, insulin-like growth factor-i, infancycardiovascular risk-factors, impaired glucose-tolerance, hormone-secretion, adult life, binding-proteins, heart-disease, fetal-growth, elderly-men, igf-i, women |
| Subjects: | Q Science > QP Physiology Q Science > QH Natural history > QH426 Genetics R Medicine > RJ Pediatrics |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease University Structure - Pre August 2011 > School of Chemistry University Structure - Pre August 2011 > School of Medicine > Human Genetics |
| Item ID: | 25630 |
| Date Deposited: | 11 Apr 2006 |
| Last Modified: | 01 Apr 2012 02:20 |
| Contributors: | Holt, R.I.G. (Author) Syddall, H.E. (Author) Phillips, D.I.W. (Author) Martyn, C.N. (Author) Gluckman, P.D. (Author) Breier, B.H. (Author) Wood, P.J. (Author) Fall, C.H. (Author) |
| Date: | April 2004 |
| Status: | Published |
| Contact Email Address: | R.I.G.Holt@soton.ac.uk |
| URI: | http://eprints.soton.ac.uk/id/eprint/25630 |
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