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The effects of the ACE gene insertion/deletion polymorphism on glucose tolerance and insulin secretion in elderly people are modified by birth weight

The effects of the ACE gene insertion/deletion polymorphism on glucose tolerance and insulin secretion in elderly people are modified by birth weight
The effects of the ACE gene insertion/deletion polymorphism on glucose tolerance and insulin secretion in elderly people are modified by birth weight
The I allele of an insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme gene (ACE) appears to be protective against the complications of type 2 diabetes. Low birth weight, a marker of an adverse intrauterine environment, is associated with higher rates of type 2 diabetes. We examined whether the ACE I/D polymorphism could explain or modify the association between low birth weight and adulthood glucose tolerance.
We measured plasma glucose and insulin concentrations after an oral glucose challenge in a group of 423 men and women, ages 65–75 yr, with measurements at birth recorded. The presence of the I allele was associated with shorter duration of gestation (P = 0.006) and, relative to gestational age, higher birth weight (P = 0.008) and length (P = 0.02). The I allele was associated with lower glucose at 120 min (P = 0.04) and a greater insulin response (P = 0.03 for insulin at 30 min and P = 0.06 for insulin area under the curve) to a standard oral glucose tolerance test. However, the associations between the ACE genotype and adulthood insulin secretion were only present in people with low birth weight (P for interaction birth weight * ACE genotype on insulin at 30 min = 0.003 and on insulin area under the curve = 0.05).
The ACE I allele is associated with shorter duration of gestation and higher birth weight. The association between the presence of the ACE I allele and increased indices of adult insulin secretion is confined to subjects with low birth weight. We suggest that these findings reflect interactions between genotype and intrauterine environment with resulting changes in gene expression.

0021-972X
5738-5741
Kajantie, Eero
d68d55b6-6df1-4195-a914-44c738a6db93
Rautanen, Anna
001dd04d-e561-44e9-9b49-fec025c5f063
Kere, Juha
57c301de-f111-4552-a585-13eed945bdfc
Andersson, Sture
31b08a06-75c5-4aa5-b879-3cb270abe81f
Yliharsila, Hilkka
43f42eb3-57cf-4a49-af0f-6672525f23d5
Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Barker, David J.P.
5c773838-b094-4ac1-999b-b5869717f243
Forsen, Tom
77245dbe-fc1f-4e6f-a2bb-6f1a77918cd2
Eriksson, Johan
bed81786-e72a-4710-a5b7-ddc6732bc45a
Kajantie, Eero
d68d55b6-6df1-4195-a914-44c738a6db93
Rautanen, Anna
001dd04d-e561-44e9-9b49-fec025c5f063
Kere, Juha
57c301de-f111-4552-a585-13eed945bdfc
Andersson, Sture
31b08a06-75c5-4aa5-b879-3cb270abe81f
Yliharsila, Hilkka
43f42eb3-57cf-4a49-af0f-6672525f23d5
Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Barker, David J.P.
5c773838-b094-4ac1-999b-b5869717f243
Forsen, Tom
77245dbe-fc1f-4e6f-a2bb-6f1a77918cd2
Eriksson, Johan
bed81786-e72a-4710-a5b7-ddc6732bc45a

Kajantie, Eero, Rautanen, Anna, Kere, Juha, Andersson, Sture, Yliharsila, Hilkka, Osmond, Clive, Barker, David J.P., Forsen, Tom and Eriksson, Johan (2004) The effects of the ACE gene insertion/deletion polymorphism on glucose tolerance and insulin secretion in elderly people are modified by birth weight. Journal of Clinical Endocrinology & Metabolism, 89 (11), 5738-5741. (doi:10.1210/jc.2004-0492).

Record type: Article

Abstract

The I allele of an insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme gene (ACE) appears to be protective against the complications of type 2 diabetes. Low birth weight, a marker of an adverse intrauterine environment, is associated with higher rates of type 2 diabetes. We examined whether the ACE I/D polymorphism could explain or modify the association between low birth weight and adulthood glucose tolerance.
We measured plasma glucose and insulin concentrations after an oral glucose challenge in a group of 423 men and women, ages 65–75 yr, with measurements at birth recorded. The presence of the I allele was associated with shorter duration of gestation (P = 0.006) and, relative to gestational age, higher birth weight (P = 0.008) and length (P = 0.02). The I allele was associated with lower glucose at 120 min (P = 0.04) and a greater insulin response (P = 0.03 for insulin at 30 min and P = 0.06 for insulin area under the curve) to a standard oral glucose tolerance test. However, the associations between the ACE genotype and adulthood insulin secretion were only present in people with low birth weight (P for interaction birth weight * ACE genotype on insulin at 30 min = 0.003 and on insulin area under the curve = 0.05).
The ACE I allele is associated with shorter duration of gestation and higher birth weight. The association between the presence of the ACE I allele and increased indices of adult insulin secretion is confined to subjects with low birth weight. We suggest that these findings reflect interactions between genotype and intrauterine environment with resulting changes in gene expression.

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Published date: 2004

Identifiers

Local EPrints ID: 25688
URI: http://eprints.soton.ac.uk/id/eprint/25688
ISSN: 0021-972X
PURE UUID: e5f587e6-2ab1-4921-bdc2-cab350036ffe
ORCID for Clive Osmond: ORCID iD orcid.org/0000-0002-9054-4655

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Date deposited: 20 Apr 2006
Last modified: 16 Mar 2024 02:50

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Contributors

Author: Eero Kajantie
Author: Anna Rautanen
Author: Juha Kere
Author: Sture Andersson
Author: Hilkka Yliharsila
Author: Clive Osmond ORCID iD
Author: David J.P. Barker
Author: Tom Forsen
Author: Johan Eriksson

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