Fetal programming of body composition: relation between birth weight and body composition measured with dual-energy x-ray absorptiometry and anthropometric methods in older Englishmen


Kensara, Osama A., Wootton, Steve A., Phillips, David I., Patel, Mayke, Jackson, Alan A. and Elia, Marinos (2005) Fetal programming of body composition: relation between birth weight and body composition measured with dual-energy x-ray absorptiometry and anthropometric methods in older Englishmen. American Journal of Clinical Nutrition, 82, (5), 980-987.

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Description/Abstract

Background: Reduced fetal growth is associated with differences in body composition in adult life that may predispose to cardiovascular disease and diabetes. Most published data are based on simple anthropometric measures, which incompletely describe body composition.

Objective: The objective was to assess body composition and fat distribution by using dual-energy X-ray absorptiometry (DXA).

Design: This was a case-control study of 64–72-y-old white men (n = 32) with a low (x: 2.76 kg) or high (x: 4.23 kg) birth weight.

Results: Compared with the high-birth-weight group, after adjustment for weight and height, the low-birth-weight group had a higher percentage body fat (29.31% compared with 25.33%; P = 0.029) and fat mass (P = 0.039) but a lower fat-free soft tissue (56.32 compared with 59.22 kg; P = 0.024), muscle mass (27.25 compared with 29.22 kg; P = 0.022), and muscle-to-fat ratio. Low birth weight was also associated with a higher trunk-to-limb fat ratio after control for total fat mass (1.42 compared with 1.16; P = 0.005) or percentage body fat (P = 0.041). The same body mass index predicted a greater percentage body fat (P = 0.019) in the low- than in the high-birth-weight group, and the same ratio of trunk-to-limb skinfold thickness (or waist-to-hip ratio) predicted a higher trunk-to-limb fat ratio (P < 0.01).

Conclusion: Lifelong differences in adult body composition and fat distribution between the low- and high-birth-weight groups are consistent with programming in early life. The use of BMI to predict percentage body fat and the use of the trunk-to-limb skinfold thickness ratio (and waist-to-hip ratio) to predict the trunk-to-limb fat ratio measured by DXA can be misleading when low- and high-birth-weight groups are compared.

Item Type: Article
Additional Information: Original research communication
ISSNs: 0002-9165 (print)
Related URLs:
Keywords: body composition, birth weight, fat, lean mass, muscle programming, body mass index, dual-energy x-ray absorptiometry, waist-to-hip ratio, fat distribution, skinfold thickness
Subjects: H Social Sciences > HT Communities. Classes. Races
R Medicine > RG Gynecology and obstetrics
Q Science > QP Physiology
Divisions: University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 25712
Date Deposited: 10 Apr 2006
Last Modified: 27 Mar 2014 18:14
Contact Email Address: elia@soton.ac.uk
URI: http://eprints.soton.ac.uk/id/eprint/25712

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