Predictive adaptive responses to maternal high-fat diet prevent endothelial dysfunction but not hypertension in adult rat offspring

Khan, Imran, Dekou, Vasia, Hanson, Mark A., Poston, Lucilla and Taylor, Paul (2004) Predictive adaptive responses to maternal high-fat diet prevent endothelial dysfunction but not hypertension in adult rat offspring. Circulation, 110, (9), 1097-1102. (doi:10.1161/01.CIR.0000139843.05436.A0).


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Background— Population-based studies suggest that fetal adaptive responses to maternal dietary imbalance confer survival benefit when the postnatal diet remains suboptimal but increase susceptibility to cardiovascular disease when postnatal nutrition is improved. We have investigated "predictive adaptive" responses in a rodent model in which adult offspring of fat-fed dams develop characteristics of the metabolic syndrome.

Methods and Results— Sprague-Dawley rats were fed a fat-rich diet or normal chow throughout pregnancy and weaning. Vascular endothelial function and blood pressure were determined in 180-day-old offspring of fat-fed dams raised on standard chow (FC) or on the fat-rich diet (FF) and in offspring of chow-fed dams raised on chow (CON). Small mesenteric artery endothelium-dependent dilation to acetylcholine was impaired in male and female FC (by ANOVA, P<0.001 versus CON) but similar to CON in FF (P=NS). Blood glucose was lower in FF versus FC. Heart rate was reduced in male FC versus CON (P<0.05) but not in FF. Plasma triglyceride concentrations were reduced in male FF compared with CON (P<0.05). Blood pressure was raised in female FC (systolic, 132.5±3.0 mm Hg versus CON, 119.0±3.8 mm Hg, P<0.05; diastolic, 91.2±1.7 mm Hg versus CON, 81.1±1.4 mm Hg, P<0.05) and in female FF (systolic, 132.5±4.2 mm Hg versus CON, P<0.05; diastolic, 91.0±1.9 mm Hg versus CON, P<0.05). Blood pressure was similar to CON in male FC and FF.

Conclusions— Predictive adaptive responses prevent endothelial dysfunction and reduced heart rate in offspring of fat-fed dams if offspring are raised on the same diet but do not prevent development of raised blood pressure.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1161/01.CIR.0000139843.05436.A0
Additional Information: Hypertension
ISSNs: 0009-7322 (print)
Related URLs:
Keywords: diet, endothelium, blood pressure, telemetry, pregnancy
Subjects: Q Science > QP Physiology
Q Science > QH Natural history > QH301 Biology
Divisions : University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 25718
Accepted Date and Publication Date:
Date Deposited: 21 Apr 2006
Last Modified: 31 Mar 2016 11:48

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