Mathematical modelling of skeletal repair

MacArthur, B.D., Please, C.P., Taylor, M. and Oreffo, R.O.C. (2004) Mathematical modelling of skeletal repair. Biochemical and Biophysical Research Communications, 313, (4), 825-833. (doi:10.1016/j.bbrc.2003.11.171).


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Tissue engineering offers significant promise as a viable alternative to current clinical strategies for replacement of damaged tissue as a consequence of disease or trauma. Since mathematical modelling is a valuable tool in the analysis of complex systems, appropriate use of mathematical models has tremendous potential for advancing the understanding of the physical processes involved in such tissue reconstruction. In this review, the potential benefits, and limitations, of theoretical modelling in tissue engineering applications are examined with specific emphasis on tissue engineering of bone. A central tissue engineering approach is the in vivo implantation of a biomimetic scaffold seeded with an appropriate population of stem or progenitor cells. This review will therefore consider the theory behind a number of key factors affecting the success of such a strategy including: stem cell or progenitor population expansion and differentiation ex vivo; cell adhesion and migration, and the effective design of scaffolds; and delivery of nutrient to avascular structures. The focus will be on current work in this area, as well as on highlighting limitations and suggesting possible directions for future work to advance health-care for all.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/j.bbrc.2003.11.171
ISSNs: 0006-291X (print)
Related URLs:
Keywords: tissue engineering, mathematical modelling, mesenchymal stem cell, porous scaffold, stem cell niche
Subjects: R Medicine > RB Pathology
R Medicine
Q Science > QH Natural history > QH301 Biology
Divisions : University Structure - Pre August 2011 > School of Engineering Sciences
University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
University Structure - Pre August 2011 > School of Mathematics
ePrint ID: 25776
Accepted Date and Publication Date:
23 January 2004Published
5 November 2003Submitted
Date Deposited: 12 Apr 2006
Last Modified: 31 Mar 2016 11:48

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