In silico modeling of asthma


Martonen, Ted, Fleming, John, Schroeter, Jeffrey, Conway, Joy and Hwang, Dongming (2003) In silico modeling of asthma. Advanced Drug Delivery Reviews, 55, (7), 829-849. (doi:10.1016/S0169-409X(03)00080-2).

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Description/Abstract

The incidence of asthma is increasing throughout the world, especially among children, to the extent that it has become a medical issue of serious global concern. Appropriately, numerous pharmacologic drugs and clinical protocols for the treatment and prophylaxis of the disease have been reported. From a scientific perspective, a review of the literature suggests that the targeted delivery of an aerosol would, in a real sense, enhance the efficacy of an inhaled medicine. Therefore, in accordance with published data we have developed a mathematical description of disease-induced effects of disease on airway morphology. A morphological algorithm defining the heterogeneity of asthma has been integrated with a computer code that formulates the behavior and fate of inhaled drugs. In this work, predicted drug particle deposition patterns have been compared with SPECT images from experiments with healthy human subjects (controls) and asthmatic patients. The asthma drug delivery model simulations agree with observations from human testing. The results indicate that in silico modeling provides a technical foundation for addressing effects of disease on the administration of aerosolized drugs, and suggest that modeling should be used in a complementary manner with future inhalation therapy protocols.

Item Type: Article
ISSNs: 0169-409X (print)
Related URLs:
Keywords: targeted drug delivery, particle deposition model, asthma morphology
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RA Public aspects of medicine
Divisions: University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 25788
Date Deposited: 19 Apr 2006
Last Modified: 27 Mar 2014 18:14
Contact Email Address: martonen.ted@epa.gov
URI: http://eprints.soton.ac.uk/id/eprint/25788

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