The Mirena(R) levonorgestrel system
McGavigan, C.J. and Cameron, I.T. (2003) The Mirena(R) levonorgestrel system. Drugs of Today, 39, (12), 973-984. (doi:10.1358/dot.2003.39.12.799415).
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The levonorgestrel intrauterine system is a safe, efficacious, long-term contraceptive device. Additionally, it results in a decrease in the volume of menstrual blood loss in women with normal periods and those with menorrhagia. It may also have a role in the treatment of other benign gynecological disorders, such as adenomyosis or endometriosis, and it has been advocated as a means of delivering progestogen to the endometrium as part of combined hormone replacement therapy. Despite the beneficial effect on menstrual volume, compliance is sometimes limited by breakthrough bleeding during the first months of use. The precise mechanism of this bleeding is unclear, but it may be related to a direct effect of levonorgestrel on endometrial vascular development. Detailed counseling is crucial to explain this anticipated side effect in order to reduce unnecessary discontinuation of treatment.
|Subjects:||R Medicine > RG Gynecology and obstetrics
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
|Date Deposited:||19 Apr 2006|
|Last Modified:||31 May 2011 23:43|
|Contact Email Address:||firstname.lastname@example.org|
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