Intrauterine exposure to a maternal low protein diet reduces adult bone mass and alters growth plate morphology in rats


Mehta, G., Roach, H.I., Langley-Evans, S., Taylor, P., Reading, I., Oreffo, R.O.C., Aihie-Sayer, A., Clarke, N.M.P. and Cooper, C. (2002) Intrauterine exposure to a maternal low protein diet reduces adult bone mass and alters growth plate morphology in rats. Calcified Tissue International, 71, (6), 493-498. (doi:10.1007/s00223-001-2104-9).

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Description/Abstract

Epidemiological studies suggest that poor growth during fetal life and infancy is associated with decreased bone mass in adulthood. However, theses observations have not, to date, been corroborated in animal models. To address this issue we evaluated the influence of maternal protein restriction on bone mass and growth plate morphology among the adult offspring, using a rat model. Maternal protein restriction resulted in a reduction in bone area and BMC, but not BMD, among the offspring in late adulthood. The widened epiphyseal growth plate in the protein-restricted offspring is compatible with the programming of cartilage and bone growth by maternal nutrition in early life.

Item Type: Article
ISSNs: 0171-967X (print)
Related URLs:
Subjects: R Medicine > RG Gynecology and obstetrics
Q Science > QP Physiology
Q Science > QH Natural history > QH301 Biology
Divisions: University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 25803
Date Deposited: 19 Apr 2006
Last Modified: 27 Mar 2014 18:14
Contact Email Address: cc@mrc.soton.ac.uk
URI: http://eprints.soton.ac.uk/id/eprint/25803

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