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Circulating levels of MCP-1 and eotaxin are not associated with presence of atherosclerosis or previous myocardial infarction

Circulating levels of MCP-1 and eotaxin are not associated with presence of atherosclerosis or previous myocardial infarction
Circulating levels of MCP-1 and eotaxin are not associated with presence of atherosclerosis or previous myocardial infarction
The chemokines are a family of signalling proteins that participate in regulation of the immune system and have been implicated in the pathogenesis of vascular diseases. Deleting the gene encoding the chemokine MCP-1 in mouse models of atherosclerosis reduces lipid lesion formation and circulating chemokines are upregulated in man immediately following myocardial infarction (MI) or coronary angioplasty. We have therefore investigated whether circulating levels of two chemokines (MCP-1 and eotaxin) differ between subjects with and without atherosclerosis. We have used three different methods of measuring the presence and extent of atherosclerosis in human subjects: duplex ultrasonography of the carotid arteries and clinical diagnosis of coronary heart disease on individuals from the general population and coronary angiography on patients with suspected heart disease. There was no difference in the levels of circulating MCP-1 or eotaxin, measured by ELISA, between subjects with and without atherosclerosis. Furthermore, any increase in circulating MCP-1 following acute MI must be short-lived, since chemokine levels were not different in subjects who had had an MI previously compared to those who had not. We conclude that although there may be a transient increase in circulating chemokine levels following coronary angioplasty, there is no difference in the levels of circulating MCP-1 or eotaxin in subjects with and without atherosclerosis.
angiography, chemokine, coronary artery disease, cytokine, immunology
0021-9150
268-274
Mosedale, D.E.
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Smith, D.J.
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Aitken, S.
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Schofield, P.M.
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Clarke, S.C.
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McNab, D.
a231273b-3b34-434a-a2b6-43fcc173f80b
Goddard, H.
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Gale, C.R.
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Martyn, C.N.
bb7ae7af-c7af-4e79-b719-216733eda771
Bethell, H.W.
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Barnard, C.
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Hayns, S.
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Nugent, C.
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Panicker, A.
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Grainger, D.J.
e352cf8f-bad4-4efa-a779-3f072ae648ab
Mosedale, D.E.
825dc2de-bb79-490f-9ce2-d6e63f5489c1
Smith, D.J.
8bf40520-48c8-4797-9ae3-d150f650b3ef
Aitken, S.
a33d58fe-5fa9-43c7-92ff-4bf5d54688b0
Schofield, P.M.
af5059ca-8a87-40ba-8ba4-ff023d9e7f27
Clarke, S.C.
ebd8bf6e-c8be-4307-8012-ca2c32e4e5f3
McNab, D.
a231273b-3b34-434a-a2b6-43fcc173f80b
Goddard, H.
732385ae-969f-4c0d-b2c4-de910bddca2a
Gale, C.R.
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Martyn, C.N.
bb7ae7af-c7af-4e79-b719-216733eda771
Bethell, H.W.
04be091e-5df3-4d01-b5bf-072809ceb7b6
Barnard, C.
09642ab8-d519-4b5a-8643-97f66854f792
Hayns, S.
91663341-d0b8-47ae-adbd-90152265dc66
Nugent, C.
590fef99-ce99-4bd9-95d2-bef32063958f
Panicker, A.
3ff74b19-c39b-415e-91fa-fcd869ded568
Grainger, D.J.
e352cf8f-bad4-4efa-a779-3f072ae648ab

Mosedale, D.E., Smith, D.J., Aitken, S., Schofield, P.M., Clarke, S.C., McNab, D., Goddard, H., Gale, C.R., Martyn, C.N., Bethell, H.W., Barnard, C., Hayns, S., Nugent, C., Panicker, A. and Grainger, D.J. (2005) Circulating levels of MCP-1 and eotaxin are not associated with presence of atherosclerosis or previous myocardial infarction. Atherosclerosis, 183 (2), 268-274. (doi:10.1016/j.atherosclerosis.2004.11.028).

Record type: Article

Abstract

The chemokines are a family of signalling proteins that participate in regulation of the immune system and have been implicated in the pathogenesis of vascular diseases. Deleting the gene encoding the chemokine MCP-1 in mouse models of atherosclerosis reduces lipid lesion formation and circulating chemokines are upregulated in man immediately following myocardial infarction (MI) or coronary angioplasty. We have therefore investigated whether circulating levels of two chemokines (MCP-1 and eotaxin) differ between subjects with and without atherosclerosis. We have used three different methods of measuring the presence and extent of atherosclerosis in human subjects: duplex ultrasonography of the carotid arteries and clinical diagnosis of coronary heart disease on individuals from the general population and coronary angiography on patients with suspected heart disease. There was no difference in the levels of circulating MCP-1 or eotaxin, measured by ELISA, between subjects with and without atherosclerosis. Furthermore, any increase in circulating MCP-1 following acute MI must be short-lived, since chemokine levels were not different in subjects who had had an MI previously compared to those who had not. We conclude that although there may be a transient increase in circulating chemokine levels following coronary angioplasty, there is no difference in the levels of circulating MCP-1 or eotaxin in subjects with and without atherosclerosis.

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More information

Published date: 2005
Keywords: angiography, chemokine, coronary artery disease, cytokine, immunology

Identifiers

Local EPrints ID: 25835
URI: http://eprints.soton.ac.uk/id/eprint/25835
ISSN: 0021-9150
PURE UUID: 3b155b62-401b-412b-bc67-6261d58b73d8
ORCID for C.R. Gale: ORCID iD orcid.org/0000-0002-3361-8638

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Date deposited: 12 Apr 2006
Last modified: 16 Mar 2024 02:49

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Contributors

Author: D.E. Mosedale
Author: D.J. Smith
Author: S. Aitken
Author: P.M. Schofield
Author: S.C. Clarke
Author: D. McNab
Author: H. Goddard
Author: C.R. Gale ORCID iD
Author: C.N. Martyn
Author: H.W. Bethell
Author: C. Barnard
Author: S. Hayns
Author: C. Nugent
Author: A. Panicker
Author: D.J. Grainger

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