Growth factors for skeletal reconstruction and fracture repair
Growth factors for skeletal reconstruction and fracture repair
The demographic challenges of an ageing population have emphasized the need for processes to augment and repair skeletal tissue loss as a consequence of trauma and/or degeneration. A number of bone growth factors have been shown to be expressed during the course of fracture healing, suggesting a potential role in bone and cartilage formation, and in fracture repair. This review focuses on a select number of these growth factors currently under preclinical and clinical evaluation for skeletal regeneration and fracture repair. The limitations in the use of these skeletal factors to augment bone growth, thus improving quality-of-life and reducing the significant social and economic costs associated with skeletal trauma/loss are also considered.
419-423
Oreffo, R.O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
2004
Oreffo, R.O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Oreffo, R.O.C.
(2004)
Growth factors for skeletal reconstruction and fracture repair.
Current Opinion in Investigational Drugs, 5 (4), .
Abstract
The demographic challenges of an ageing population have emphasized the need for processes to augment and repair skeletal tissue loss as a consequence of trauma and/or degeneration. A number of bone growth factors have been shown to be expressed during the course of fracture healing, suggesting a potential role in bone and cartilage formation, and in fracture repair. This review focuses on a select number of these growth factors currently under preclinical and clinical evaluation for skeletal regeneration and fracture repair. The limitations in the use of these skeletal factors to augment bone growth, thus improving quality-of-life and reducing the significant social and economic costs associated with skeletal trauma/loss are also considered.
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Published date: 2004
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Local EPrints ID: 25862
URI: http://eprints.soton.ac.uk/id/eprint/25862
ISSN: 1472-4472
PURE UUID: 473432d7-df09-4413-a6c2-bb1fd7ccbe6c
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Date deposited: 11 Apr 2006
Last modified: 09 Jan 2022 03:02
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