Early programming of weight gain in mice prevents the induction of obesity by a highly palatable diet
Early programming of weight gain in mice prevents the induction of obesity by a highly palatable diet
Poor early growth is associated with Type II diabetes, hypertension and other features of the metabolic syndrome in adulthood. It has been suggested that this results from the development of a thrifty phenotype by a malnourished fetus. Such a phenotype would predispose the offspring to the development of obesity if born into conditions of over-nutrition. The present study aimed to determine if early nutrition affected subsequent development of obesity. Mice were established as follows: (a) controls (offspring of control dams), (b) recuperated (offspring of dams fed a low-protein diet during pregnancy, but nursed by control dams) and (c) postnatal low-protein (offspring of control dams nursed by low-protein-fed dams). Mice were weaned on to standard laboratory chow or a cafeteria diet. Recuperated offspring, although smaller at birth (P<0.01), caught up and exceeded the weight of control offspring by 7 days of age (P<0.001). Postnatal low-protein offspring were smaller than controls by 7 days of age (P<0.001). Recuperated animals gained more weight than controls when given free access to a highly palatable diet (P<0.01). Postnatal low-protein animals showed no additional weight gain when given a highly palatable diet compared with chow-fed litter-mates. These results suggest that the early environment has long-term consequences for weight gain. These programmed responses are powerful enough to block excess weight gain from a highly palatable diet and, thus, have major implications for the drug-free regulation of food intake and obesity.
appetite, catch-up growth, diet, growth restriction, obesity, Type II diabetes
141-145
Ozanne, Susan E.
bba0ebbc-1d8d-497c-ad46-518ca6e52f3a
Lewis, Rohan
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
Jennings, Bridget J.
c82fb748-525e-4f8c-8fed-53663fecb88c
Hales, Nicholas C.
14daf671-be21-4659-b816-44b0f2413a31
2004
Ozanne, Susan E.
bba0ebbc-1d8d-497c-ad46-518ca6e52f3a
Lewis, Rohan
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
Jennings, Bridget J.
c82fb748-525e-4f8c-8fed-53663fecb88c
Hales, Nicholas C.
14daf671-be21-4659-b816-44b0f2413a31
Ozanne, Susan E., Lewis, Rohan, Jennings, Bridget J. and Hales, Nicholas C.
(2004)
Early programming of weight gain in mice prevents the induction of obesity by a highly palatable diet.
Clinical Science, 106 (2), .
(doi:10.1042/CS20030278).
Abstract
Poor early growth is associated with Type II diabetes, hypertension and other features of the metabolic syndrome in adulthood. It has been suggested that this results from the development of a thrifty phenotype by a malnourished fetus. Such a phenotype would predispose the offspring to the development of obesity if born into conditions of over-nutrition. The present study aimed to determine if early nutrition affected subsequent development of obesity. Mice were established as follows: (a) controls (offspring of control dams), (b) recuperated (offspring of dams fed a low-protein diet during pregnancy, but nursed by control dams) and (c) postnatal low-protein (offspring of control dams nursed by low-protein-fed dams). Mice were weaned on to standard laboratory chow or a cafeteria diet. Recuperated offspring, although smaller at birth (P<0.01), caught up and exceeded the weight of control offspring by 7 days of age (P<0.001). Postnatal low-protein offspring were smaller than controls by 7 days of age (P<0.001). Recuperated animals gained more weight than controls when given free access to a highly palatable diet (P<0.01). Postnatal low-protein animals showed no additional weight gain when given a highly palatable diet compared with chow-fed litter-mates. These results suggest that the early environment has long-term consequences for weight gain. These programmed responses are powerful enough to block excess weight gain from a highly palatable diet and, thus, have major implications for the drug-free regulation of food intake and obesity.
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Published date: 2004
Keywords:
appetite, catch-up growth, diet, growth restriction, obesity, Type II diabetes
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Local EPrints ID: 25868
URI: http://eprints.soton.ac.uk/id/eprint/25868
ISSN: 0143-5221
PURE UUID: 89f266ef-5780-4542-8027-45d3045e0964
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Date deposited: 21 Apr 2006
Last modified: 16 Mar 2024 03:21
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Author:
Susan E. Ozanne
Author:
Bridget J. Jennings
Author:
Nicholas C. Hales
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