Is birthweight associated with thyroid autoimmunity? A study in twins
Is birthweight associated with thyroid autoimmunity? A study in twins
Although extensive studies have suggested that an individual's predisposition to develop autoantibodies to thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) has a genetic component, a recent report has suggested that growth restriction during fetal life may also contribute. We have therefore measured TPOAb and TgAb in a population-based study of twins (44 monozygous and 91 dizygous) born between 1950 and 1955 who were identified through a registry of birth records in Birmingham, United Kingdom. TPOAb and TgAb were measured by a highly sensitive immunoprecipitation assay in which 0.01 U/mL and 0.1 U/mL, respectively, were detectable. TPOAb were found in 49 of 156 (31%) of women and 7 of 116 (6%) of men with similar values for TgAb (31% and 9%, respectively). Of 28 monozygous pairs, 10 were concordant for TgAb and 7 discordant giving a probandwise concordance rate of 74%. Concordance rates for TPOAb were similar (64%) and were higher than concordance rates in dizygous twins. Monozygous twins had a higher prevalence of TgAb than dizygous twins (30% vs. 17%, p = 0.01). In addition, we found that where there was discordance in birth size within monozygous twin pairs, the smaller twin had a higher prevalence of TPOAb (p = 0.01). Our results suggest that both heritable and early environmental components contribute to the susceptibility to thyroid autoimmunity.
377-380
Phillips, David I.W.
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Osmond, Clive
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Baird, Janis
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Huckle, Alison
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Rees-Smith, Bernard
c7b04994-3388-4689-838f-710a3a781433
May 2002
Phillips, David I.W.
29b73be7-2ff9-4fff-ae42-d59842df4cc6
Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Baird, Janis
f4bf2039-6118-436f-ab69-df8b4d17f824
Huckle, Alison
62fde35d-d11b-4884-8d71-59fa3eb05c2e
Rees-Smith, Bernard
c7b04994-3388-4689-838f-710a3a781433
Phillips, David I.W., Osmond, Clive, Baird, Janis, Huckle, Alison and Rees-Smith, Bernard
(2002)
Is birthweight associated with thyroid autoimmunity? A study in twins.
Thyroid, 12 (5), .
(doi:10.1089/105072502760043440).
Abstract
Although extensive studies have suggested that an individual's predisposition to develop autoantibodies to thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) has a genetic component, a recent report has suggested that growth restriction during fetal life may also contribute. We have therefore measured TPOAb and TgAb in a population-based study of twins (44 monozygous and 91 dizygous) born between 1950 and 1955 who were identified through a registry of birth records in Birmingham, United Kingdom. TPOAb and TgAb were measured by a highly sensitive immunoprecipitation assay in which 0.01 U/mL and 0.1 U/mL, respectively, were detectable. TPOAb were found in 49 of 156 (31%) of women and 7 of 116 (6%) of men with similar values for TgAb (31% and 9%, respectively). Of 28 monozygous pairs, 10 were concordant for TgAb and 7 discordant giving a probandwise concordance rate of 74%. Concordance rates for TPOAb were similar (64%) and were higher than concordance rates in dizygous twins. Monozygous twins had a higher prevalence of TgAb than dizygous twins (30% vs. 17%, p = 0.01). In addition, we found that where there was discordance in birth size within monozygous twin pairs, the smaller twin had a higher prevalence of TPOAb (p = 0.01). Our results suggest that both heritable and early environmental components contribute to the susceptibility to thyroid autoimmunity.
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Published date: May 2002
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Local EPrints ID: 25902
URI: http://eprints.soton.ac.uk/id/eprint/25902
ISSN: 1050-7256
PURE UUID: 7148f873-d61a-4d65-96f7-671965139d5d
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Date deposited: 11 Apr 2006
Last modified: 16 Mar 2024 03:29
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Author:
David I.W. Phillips
Author:
Alison Huckle
Author:
Bernard Rees-Smith
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