DNA as a vehicle for the self-assembly model of computing
Conrad, M. and Zauner, K.-P. (1998) DNA as a vehicle for the self-assembly model of computing. BioSystems, 45, (1), 59-66.
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Description/Abstract
A DNA version of the self-assembly model of computing, feasible using currently available laboratory techniques, is proposed. Input signals are coded into unmethylated and methylated oligonucleotides which then hybridize with a backbone that contains complementary sequences. Different input signal patterns are thus represented as DNA duplexes with distinctly different conformational dynamics, in particular different equilibria of B and Z DNA. The pattern classification activity of the system is mediated by the interactions that lead to the secondary structural organization. Circular dichroism may be used for readout.
| Item Type: | Article |
|---|---|
| Keywords: | DNA computing; Self-assembly; Conformational dynamics; Pattern recognition; Molecular computing |
| Divisions: | Faculty of Physical and Applied Science > Electronics and Computer Science > Agents, Interactions & Complexity |
| Item ID: | 259026 |
| Date Deposited: | 12 Mar 2004 |
| Last Modified: | 12 Aug 2012 00:14 |
| Contributors: | Conrad, M. (Author) Zauner, K.-P. (Author) |
| Date: | 1998 |
| Status: | Published |
| Further Information: | Google Scholar |
| ISI Citation Count: | 15 |
| URI: | http://eprints.soton.ac.uk/id/eprint/259026 |
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