DNA as a vehicle for the self-assembly model of computing
Conrad, M. and Zauner, K.-P. (1998) DNA as a vehicle for the self-assembly model of computing. BioSystems, 45, (1), 59-66.
A DNA version of the self-assembly model of computing, feasible using currently available laboratory techniques, is proposed. Input signals are coded into unmethylated and methylated oligonucleotides which then hybridize with a backbone that contains complementary sequences. Different input signal patterns are thus represented as DNA duplexes with distinctly different conformational dynamics, in particular different equilibria of B and Z DNA. The pattern classification activity of the system is mediated by the interactions that lead to the secondary structural organization. Circular dichroism may be used for readout.
|Keywords:||DNA computing; Self-assembly; Conformational dynamics; Pattern recognition; Molecular computing|
|Divisions:||Faculty of Physical and Applied Science > Electronics and Computer Science > Agents, Interactions & Complexity
|Date Deposited:||12 Mar 2004|
|Last Modified:||12 Aug 2012 00:14|
|Contributors:||Conrad, M. (Author)
Zauner, K.-P. (Author)
|Further Information:||Google Scholar|
|ISI Citation Count:||15|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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