Zauner, K.-P. and Conrad, M. (2001) Enzymatic Computing. Biotechnology Progress, 17, (3), 553-559.
The conformational dynamics of enzymes is a computational resource that fuses milieu signals in a nonlinear fashion. Response surface methodology can be used to elicit computational functionality from enzyme dynamics. We constructed a tabletop prototype to implement enzymatic signal processing in a device context and employed it in conjunction with malate dehydrogenase to perform the linearly inseparable exclusive-or operation. This shows that proteins can execute signal processing operations that are more complex than those performed by individual threshold elements. We view the experiments reported, though restricted to the two-variable case, as a stepping stone to computational networks that utilize the precise reproduc- ibility of proteins, and the concomitant reproducibility of their nonlinear dynamics, to implement complex pattern transformations.
|Keywords:||Molecular Computing, conformation-based computing, malate dehydrogenase, enzyme kinetics, nanotechnology|
|Divisions:||Faculty of Physical and Applied Science > Electronics and Computer Science > Agents, Interactions & Complexity
|Date Deposited:||12 Mar 2004|
|Last Modified:||15 Aug 2012 03:11|
|Contributors:||Zauner, K.-P. (Author)
Conrad, M. (Author)
|Further Information:||Google Scholar|
|ISI Citation Count:||26|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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