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Catabolic and anabolic phases of osteodystrophy in aged rats

Catabolic and anabolic phases of osteodystrophy in aged rats
Catabolic and anabolic phases of osteodystrophy in aged rats
The aims of this study were to investigate the incidence and characteristics of osteodystrophy that occurred in rats which were maintained until death without experimental intervention. We defined and characterized catabolic and anabolic phases of osteodystrophy, based on the morphology of the cortical bone. During the catabolic phase, large resorption cavities appeared within the cortical bone. During the anabolic phase, progressively increased amounts of new bone was formed, which partially or completely filled previous resorption cavities and also extended into the medullary space. Contrary to previous experimental studies of renal failure in rats, which documented suppression of bone formation, the present studies found that the majority of rats displayed evidence of an anabolic phase with extensive new bone formation. The new bone originated within and around fibers that had formed adjacent to bone trabeculae or within resorption cavities. Hence, osteitis fibrosa was a preliminary stage to de novo bone formation. There was an association between the incidence of osteodystrophy and kidney failure as the cause of death, and it is proposed that the observed osteodystrophy had been a consequence of secondary hyperparathyroidism due to renal failure.
osteodystrophy, pth, bone formation, anabolic, catabolic, rat, old age
0914-8779
299-306
Roach, Helmtrud I.
ca2ff1f4-1ada-4c56-9097-cd27ca4d199e
Clarke, Nicholas M.P.
76688c21-d51e-48fa-a84d-deec66baf8ac
Langley-Evans, Simon
dd756517-c254-4a22-95d2-4b3e09edca8e
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Roach, Helmtrud I.
ca2ff1f4-1ada-4c56-9097-cd27ca4d199e
Clarke, Nicholas M.P.
76688c21-d51e-48fa-a84d-deec66baf8ac
Langley-Evans, Simon
dd756517-c254-4a22-95d2-4b3e09edca8e
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6

Roach, Helmtrud I., Clarke, Nicholas M.P., Langley-Evans, Simon and Cooper, Cyrus (2003) Catabolic and anabolic phases of osteodystrophy in aged rats. Journal of Bone and Mineral Metabolism, 21 (5), 299-306. (doi:10.1007/s00774-003-0424-8).

Record type: Article

Abstract

The aims of this study were to investigate the incidence and characteristics of osteodystrophy that occurred in rats which were maintained until death without experimental intervention. We defined and characterized catabolic and anabolic phases of osteodystrophy, based on the morphology of the cortical bone. During the catabolic phase, large resorption cavities appeared within the cortical bone. During the anabolic phase, progressively increased amounts of new bone was formed, which partially or completely filled previous resorption cavities and also extended into the medullary space. Contrary to previous experimental studies of renal failure in rats, which documented suppression of bone formation, the present studies found that the majority of rats displayed evidence of an anabolic phase with extensive new bone formation. The new bone originated within and around fibers that had formed adjacent to bone trabeculae or within resorption cavities. Hence, osteitis fibrosa was a preliminary stage to de novo bone formation. There was an association between the incidence of osteodystrophy and kidney failure as the cause of death, and it is proposed that the observed osteodystrophy had been a consequence of secondary hyperparathyroidism due to renal failure.

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More information

Published date: September 2003
Keywords: osteodystrophy, pth, bone formation, anabolic, catabolic, rat, old age

Identifiers

Local EPrints ID: 25937
URI: http://eprints.soton.ac.uk/id/eprint/25937
ISSN: 0914-8779
PURE UUID: 95d2e19d-b893-4cde-8939-08fcc8cdd517
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709

Catalogue record

Date deposited: 24 Apr 2006
Last modified: 18 Mar 2024 02:44

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Contributors

Author: Helmtrud I. Roach
Author: Simon Langley-Evans
Author: Cyrus Cooper ORCID iD

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