Some effects of sustained compression on ulcerated tissues
Roberts, Geoff, Hammad, Lina, Collins, Carol, Shearman, Cliff and Mani, Raj (2002) Some effects of sustained compression on ulcerated tissues. Angiology, 53, (4), 451-456. (doi:10.1177/000331970205300412).
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Sustained leg compression is the first line of treatment for patients with chronic venous ulcers. The success rates of this treatment vary, and the mode(s) of action are not well understood. In this study, tissue oxygen tension (TcPO2), surface pH, and reactive hyperemia measurements were made to observe changes associated with sustained compression in patients with chronic venous ulcers. Patients with chronic venous ulcers (n = 20, 13 F, 7 M, median age 65.5 years, median ulcer size 13.9 cm2) were assigned to the same treatment, wound dressings, and 4-layer bandaging during a 24-week period. Duplex ultrasound, venous refilling time, skin tissue oxygen, and ulcer surface pH were measured at defined time points. Ulcer areas were calculated from contour traces done at regular dressing changes. The difference between ulcer surface pH and control values measured proximally on the same leg diminished with healing (p = 0.02), which occurred despite the evidence of deep venous reflux. Ulcers with smaller initial areas healed quicker (p = 0.003). A greater likelihood of healing was observed in women (p = 0.017). Sustained compression may potentiate healing by acting on the microcirculation in ulcerated tissues.
|Subjects:||R Medicine > RM Therapeutics. Pharmacology
Q Science > QP Physiology
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
|Date Deposited:||11 Apr 2006|
|Last Modified:||06 Aug 2015 02:26|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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