n-3 polyunsaturated fatty acids and colon cancer prevention
Roynette, Catherine E., Calder, Philip C., Dupertuis, Yves M. and Pichard, Claude (2004) n-3 polyunsaturated fatty acids and colon cancer prevention. Clinical Nutrition, 23, (2), 139-151. (doi:10.1016/j.clnu.2003.07.005).
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The incidence of colon cancer in industrialised countries has increased since the early 1970s. It is estimated that more than one-third of cases are associated with factors related to a Western diet. Both the type and amount of dietary fats consumed have been implicated in colon cancer aetiology. Recent studies have demonstrated that n-3 polyunsaturated fatty acids (PUFAs), commonly found in fish oil (FO), could prevent colon cancer development. Evidences show that n-3 PUFAs act at different stages of cancer development and through several mechanisms including the modulation of arachidonic acid-derived prostaglandin synthesis, and Ras protein and protein kinase C expression and activity. As a result, n-3 PUFAs limit tumour cell proliferation, increase apoptotic potential along the crypt axis, promote cell differentiation and possibly limit angiogenesis. The modulatory actions of n-3 PUFAs on the immune system and their anti-inflammatory effects might also play a role in reducing colon carcinogenesis. There remains, nevertheless, some ambiguity over the safety of n-3 PUFAs with respect to secondary tumour formation. However, it appears that n-3 PUFAs may be of use in colon cancer prevention.
|Digital Object Identifier (DOI):||doi:10.1016/j.clnu.2003.07.005|
|Additional Information:||Review Article|
|Keywords:||colon cancer; n-3 Fatty acids, immuno-modulatory nutrition, prevention|
|Subjects:||R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
|Date Deposited:||12 Apr 2006|
|Last Modified:||06 Aug 2015 02:26|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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