Birth weight, infant weight gain, and cause-specific mortality: the Hertfordshire Cohort Study


Syddall, H.E., Aihie-Sayer, A., Simmonds, S.J., Osmond, C., Cox, V., Dennison, E.M., Barker, D.J.P. and Cooper, C. (2005) Birth weight, infant weight gain, and cause-specific mortality: the Hertfordshire Cohort Study. American Journal of Epidemiology, 161, (11), 1074-1080. (doi:10.1093/aje/kwi137).

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Original Publication URL: http://dx.doi.org/10.1093/aje/kwi137

Description/Abstract

Low birth weight, a marker of adverse intrauterine circumstances, is known to be associated with a range of disease outcomes in later life, including coronary heart disease, hypertension, type 2 diabetes, and osteoporosis. However, it may also decrease the risk of other common conditions, most notably neoplastic disease. The authors describe the associations between birth weight, infant weight gain, and a range of mortality outcomes in the Hertfordshire Cohort. This study included 37,615 men and women born in Hertfordshire, United Kingdom, in 1911–1939; 7,916 had died by the end of 1999. For men, lower birth weight was associated with increased risk of mortality from circulatory disease (hazard ratio per standard deviation decrease in birth weight = 1.08, 95% confidence interval: 1.04, 1.11) and from accidental falls but with decreased risk of mortality from cancer (hazard ratio per standard deviation decrease in birth weight = 0.94, 95% confidence interval: 0.90, 0.98). For women, lower birth weight was associated with a significantly (p < 0.05) increased risk of mortality from circulatory and musculoskeletal disease, pneumonia, injury, and diabetes. Overall, a one-standard-deviation increase in birth weight reduced all-cause mortality risk by age 75 years by 0.86% for both men and women.

Item Type: Article
ISSNs: 0002-9262 (print)
Related URLs:
Keywords: birth weight, cohort studies, infant;,mortality,risk,weight gain
Subjects: R Medicine > RG Gynecology and obstetrics
Divisions: University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 26009
Date Deposited: 12 Apr 2006
Last Modified: 27 Mar 2014 18:14
URI: http://eprints.soton.ac.uk/id/eprint/26009

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