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Public health impact of adverse bone effects of oral corticosteroids

Public health impact of adverse bone effects of oral corticosteroids
Public health impact of adverse bone effects of oral corticosteroids
Aims: The objective of this study was to estimate the number of fractures attributed to oral corticosteroid use.
Methods: Information was obtained from the General Practice Research Database which contains medical records of general practitioners in the UK. The total number of corticosteroid-related fractures during a course of treatment was estimated using the formula for attributable risk among the exposed.
Results: A total of 244 235 patients was prescribed an oral corticosteroid. The rate of hip fractures increased exponentially with age in both males and females. The excess number of hip fracture cases among females aged 85 years or older using 7.5 mg prednisolone per day or more was 1.4 cases per 100 patients per year. About 47% of all hip and 72% of all vertebral fractures that occurred can be attributed to oral corticosteroid use. Among 10 000 female users of higher doses, 99.7 nonvertebral, 31.6 hip and 45.8 vertebral fractures can be attributed to use of oral corticosteroids.
Conclusions: The targeting of high-risk patients will be important for implementing preventative strategies in a cost-effective manner.
fractures, oral corticosteroids, public health
0306-5251
601-607
Van Staa, T.P.
31b8bfb4-4e1b-4a48-a5a6-90ca601b94af
Abenhaim, L.
98b3a822-aed6-4c7d-bfbf-292b6b11134a
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Zhang, B.
0944e483-9118-4f70-9815-acdcad5dfeec
Leufkens, H.G.M.
04854167-bea6-4508-a8e2-aeb920a2d6b1
Van Staa, T.P.
31b8bfb4-4e1b-4a48-a5a6-90ca601b94af
Abenhaim, L.
98b3a822-aed6-4c7d-bfbf-292b6b11134a
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Zhang, B.
0944e483-9118-4f70-9815-acdcad5dfeec
Leufkens, H.G.M.
04854167-bea6-4508-a8e2-aeb920a2d6b1

Van Staa, T.P., Abenhaim, L., Cooper, C., Zhang, B. and Leufkens, H.G.M. (2001) Public health impact of adverse bone effects of oral corticosteroids. British Journal of Clinical Pharmacology, 51 (6), 601-607. (doi:10.1046/j.0306-5251.2001.bjcp.1385.x).

Record type: Article

Abstract

Aims: The objective of this study was to estimate the number of fractures attributed to oral corticosteroid use.
Methods: Information was obtained from the General Practice Research Database which contains medical records of general practitioners in the UK. The total number of corticosteroid-related fractures during a course of treatment was estimated using the formula for attributable risk among the exposed.
Results: A total of 244 235 patients was prescribed an oral corticosteroid. The rate of hip fractures increased exponentially with age in both males and females. The excess number of hip fracture cases among females aged 85 years or older using 7.5 mg prednisolone per day or more was 1.4 cases per 100 patients per year. About 47% of all hip and 72% of all vertebral fractures that occurred can be attributed to oral corticosteroid use. Among 10 000 female users of higher doses, 99.7 nonvertebral, 31.6 hip and 45.8 vertebral fractures can be attributed to use of oral corticosteroids.
Conclusions: The targeting of high-risk patients will be important for implementing preventative strategies in a cost-effective manner.

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More information

Published date: 2001
Keywords: fractures, oral corticosteroids, public health

Identifiers

Local EPrints ID: 26058
URI: http://eprints.soton.ac.uk/id/eprint/26058
ISSN: 0306-5251
PURE UUID: fcbdc18b-3924-444d-b866-30c2d9e5d8c5
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 24 Apr 2006
Last modified: 18 Mar 2024 02:44

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Contributors

Author: T.P. Van Staa
Author: L. Abenhaim
Author: C. Cooper ORCID iD
Author: B. Zhang
Author: H.G.M. Leufkens

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