Protein Folding and the Robustness of Cells

Tan, G. J. Shawn, Revilla, Ferran D. and Zauner, Klaus-Peter (2005) Protein Folding and the Robustness of Cells. In, Sixth International Workshop on Information Processing in Cells and Tissues, St. William's College, York, 30 Aug - 01 Sep 2005. , 318-332.

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The intricate intracellular infrastructure of all known life forms is based on proteins. The folded shape of a protein determines both the protein's function and the set of molecules it will bind to. This tight coupling between a protein's function and its interconnections in the molecular interaction network has consequences for the molecular course of evolution. It is also counter to human engineering approaches. Here we report on a simulation study investigating the impact of random errors in an abstract metabolic network of 500 enzymes. Tight coupling between function and interconnectivity of nodes is compared to the case where these two properties are independent. Our results show that the model system under consideration is more robust if function and interconnection are intertwined. These findings are discussed in the context of nano-systems engineering.

Item Type: Conference or Workshop Item (Paper)
Additional Information: Event Dates: Aug. 30--Sept. 1, 2005
Keywords: self-isolation, organic devices, complex networks, nano engineering, evolvability, modularity
Divisions : Faculty of Physical Sciences and Engineering > Electronics and Computer Science > Agents, Interactions & Complexity
ePrint ID: 261293
Accepted Date and Publication Date:
Date Deposited: 06 Oct 2005
Last Modified: 31 Mar 2016 14:03
Further Information:Google Scholar

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