Expression of AdipoR1 in vivo in skeletal muscle is independently associated with measures of truncal obesity in middle-aged Caucasian men
Zhang, Junlong, Holt, Helen, Wang, Chunli, Hadid, Omar H. and Byrne, Christopher D. (2005) Expression of AdipoR1 in vivo in skeletal muscle is independently associated with measures of truncal obesity in middle-aged Caucasian men. Diabetes Care, 28, (8), 2058-2060. (doi:10.2337/diacare.28.8.2058).
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The insulin-sensitizing effect of adiponectin (1–4) is mediated via adiponectin receptors (AdipoR1 and AdipoR2) (5). AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is also expressed in the liver, with lower levels of expression in skeletal muscle (5). Both receptors are expressed in adipose tissue (6) and pancreatic ß-cells (7).
It has been shown recently that expression of AdipoRs in human skeletal muscle is correlated with insulin sensitivity (8). Because central obesity is associated with insulin resistance, we have undertaken detailed measurements of body fatness with bioimpedance, dual-energy X-ray absorbtiometry (DEXA), and five-slice magnetic resonance imaging (MRI) through the abdomen. We have determined whether expression of AdipoRs was associated with body fatness and in particular with measures of central obesity.
|Digital Object Identifier (DOI):||doi:10.2337/diacare.28.8.2058|
|Additional Information:||Pathophysiology/complications: brief report|
|Subjects:||H Social Sciences > HT Communities. Classes. Races
R Medicine > RB Pathology
Q Science > QP Physiology
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
|Date Deposited:||19 Apr 2006|
|Last Modified:||31 Mar 2016 11:48|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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