Expression of AdipoR1 in vivo in skeletal muscle is independently associated with measures of truncal obesity in middle-aged Caucasian men


Zhang, Junlong, Holt, Helen, Wang, Chunli, Hadid, Omar H. and Byrne, Christopher D. (2005) Expression of AdipoR1 in vivo in skeletal muscle is independently associated with measures of truncal obesity in middle-aged Caucasian men. Diabetes Care, 28, (8), 2058-2060. (doi:10.2337/diacare.28.8.2058).

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Description/Abstract

The insulin-sensitizing effect of adiponectin (1–4) is mediated via adiponectin receptors (AdipoR1 and AdipoR2) (5). AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is also expressed in the liver, with lower levels of expression in skeletal muscle (5). Both receptors are expressed in adipose tissue (6) and pancreatic ß-cells (7).

It has been shown recently that expression of AdipoRs in human skeletal muscle is correlated with insulin sensitivity (8). Because central obesity is associated with insulin resistance, we have undertaken detailed measurements of body fatness with bioimpedance, dual-energy X-ray absorbtiometry (DEXA), and five-slice magnetic resonance imaging (MRI) through the abdomen. We have determined whether expression of AdipoRs was associated with body fatness and in particular with measures of central obesity.

Item Type: Article
Digital Object Identifier (DOI): doi:10.2337/diacare.28.8.2058
Additional Information: Pathophysiology/complications: brief report
ISSNs: 0149-5992 (print)
Related URLs:
Subjects: H Social Sciences > HT Communities. Classes. Races
R Medicine > RB Pathology
Q Science > QP Physiology
Divisions: University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 26156
Date :
Date Event
August 2005Published
Date Deposited: 19 Apr 2006
Last Modified: 31 Mar 2016 11:48
URI: http://eprints.soton.ac.uk/id/eprint/26156

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