Assembly and export of MHC class I peptide ligands
Antoniou, Antony N., Powis, Simon J. and Elliott, Tim (2003) Assembly and export of MHC class I peptide ligands. Current Opinion in Immunology, 15, (1), 75-81. (doi:10.1016/S0952-7915(02)00010-9).
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Description/Abstract
During the assembly of MHC class I molecules with peptide, a series of transient interactions are made with endoplasmic reticulum-resident chaperones and MHC class I-specific accessory molecules. These interactions culminate in the trafficking of MHC class I molecules to the cell surface and presentation of peptide to CD8+ T lymphocytes. Recent studies have revealed just how important these early interactions are, and how they influence the quality control of assembly and the optimisation of peptide–ligand binding.
| Item Type: | Article |
|---|---|
| ISSNs: | 0952-7915 (print) |
| Related URLs: | |
| Subjects: | R Medicine > R Medicine (General) Q Science > QR Microbiology > QR180 Immunology |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Cancer Sciences |
| Item ID: | 26200 |
| Date Deposited: | 20 Apr 2006 |
| Last Modified: | 01 Jun 2011 04:11 |
| Contributors: | Antoniou, Antony N. (Author) Powis, Simon J. (Author) Elliott, Tim (Author) |
| Date: | 2003 |
| Status: | Published |
| Contact Email Address: | a.n.antoniou@dundee.ac.uk |
| URI: | http://eprints.soton.ac.uk/id/eprint/26200 |
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