Assembly and export of MHC class I peptide ligands
Antoniou, Antony N., Powis, Simon J. and Elliott, Tim (2003) Assembly and export of MHC class I peptide ligands. Current Opinion in Immunology, 15, (1), 75-81. (doi:10.1016/S0952-7915(02)00010-9).
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During the assembly of MHC class I molecules with peptide, a series of transient interactions are made with endoplasmic reticulum-resident chaperones and MHC class I-specific accessory molecules. These interactions culminate in the trafficking of MHC class I molecules to the cell surface and presentation of peptide to CD8+ T lymphocytes. Recent studies have revealed just how important these early interactions are, and how they influence the quality control of assembly and the optimisation of peptide–ligand binding.
|Subjects:||R Medicine > R Medicine (General)
Q Science > QR Microbiology > QR180 Immunology
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Cancer Sciences
|Date Deposited:||20 Apr 2006|
|Last Modified:||01 Jun 2011 04:11|
|Contributors:||Antoniou, Antony N. (Author)
Powis, Simon J. (Author)
Elliott, Tim (Author)
|Contact Email Address:||email@example.com|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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