Assembly and export of MHC class I peptide ligands
Assembly and export of MHC class I peptide ligands
During the assembly of MHC class I molecules with peptide, a series of transient interactions are made with endoplasmic reticulum-resident chaperones and MHC class I-specific accessory molecules. These interactions culminate in the trafficking of MHC class I molecules to the cell surface and presentation of peptide to CD8+ T lymphocytes. Recent studies have revealed just how important these early interactions are, and how they influence the quality control of assembly and the optimisation of peptide–ligand binding.
75-81
Antoniou, Antony N.
3d711a3b-f688-46f9-823e-5bb925d10ea8
Powis, Simon J.
1bdcdc68-9097-459d-9675-7bb408316bf9
Elliott, Tim
16670fa8-c2f9-477a-91df-7c9e5b453e0e
2003
Antoniou, Antony N.
3d711a3b-f688-46f9-823e-5bb925d10ea8
Powis, Simon J.
1bdcdc68-9097-459d-9675-7bb408316bf9
Elliott, Tim
16670fa8-c2f9-477a-91df-7c9e5b453e0e
Antoniou, Antony N., Powis, Simon J. and Elliott, Tim
(2003)
Assembly and export of MHC class I peptide ligands.
Current Opinion in Immunology, 15 (1), .
(doi:10.1016/S0952-7915(02)00010-9).
Abstract
During the assembly of MHC class I molecules with peptide, a series of transient interactions are made with endoplasmic reticulum-resident chaperones and MHC class I-specific accessory molecules. These interactions culminate in the trafficking of MHC class I molecules to the cell surface and presentation of peptide to CD8+ T lymphocytes. Recent studies have revealed just how important these early interactions are, and how they influence the quality control of assembly and the optimisation of peptide–ligand binding.
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Published date: 2003
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Local EPrints ID: 26200
URI: http://eprints.soton.ac.uk/id/eprint/26200
ISSN: 0952-7915
PURE UUID: 972c1bb7-0082-4eb8-8f98-a71c56b92b99
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Date deposited: 20 Apr 2006
Last modified: 16 Mar 2024 03:19
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Author:
Antony N. Antoniou
Author:
Simon J. Powis
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