Polymorphic variation in CYP19 and the risk of breast cancer


Baxter, S.W., Choong, D.Y.H., Eccles, D.M. and Campbell, I.G. (2001) Polymorphic variation in CYP19 and the risk of breast cancer. Carcinogenesis, 22, (2), 347-349.

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Description/Abstract

The production of estrogen from androgen via the estrogen biosynthesis pathway is catalyzed by aromatase P450 (cyp19). We have assessed the frequency of allelic variants of the CYP19 intron 4 [TTTA]n repeat in 327 breast cancer cases and 253 controls from southern England. Previous studies have suggested that the [TTTA]10 repeat and [TTTA]12 repeat variants represent low penetrance breast cancer susceptibility alleles. Compared with controls our breast cancer cases had a statistically significant positive association with the [TTTA]10 allele (1.5 versus 0.2%, P = 0.028) and the [TTTA]8 allele (13.5 versus 8.7%, P = 0.012). The frequency of the [TTTA]12 allele was not significantly elevated in our study group compared with controls (2.3 versus 2.2%, P = 1.00). The CYP19 intron 4 [TTTA]n repeat is unlikely to have a functional effect on aromatase activity and it is more likely that the [TTTA]8 and [TTTA]10 variants are in linkage disequilibrium with other functional CYP19 variants.

Item Type: Article
Additional Information: Short Communication
ISSNs: 0143-3334 (print)
Related URLs:
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: University Structure - Pre August 2011 > School of Medicine > Cancer Sciences
ePrint ID: 26215
Date Deposited: 21 Apr 2006
Last Modified: 27 Mar 2014 18:15
Contact Email Address: i.campbell@pmci.unimelb.edu.au
URI: http://eprints.soton.ac.uk/id/eprint/26215

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