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Hypercalcaemia, parathyroid hormone-related protein and malignancy

Hypercalcaemia, parathyroid hormone-related protein and malignancy
Hypercalcaemia, parathyroid hormone-related protein and malignancy
Hypercalcaemia is the most common serious metabolic complication of malignancy. Recent advances have significantly increased our understanding of the pathophysiology of hypercalcaemia of malignancy and revealed the importance of parathyroid hormone-related protein (PTHrP) in a wide range of physiological and pathological processes. This review examines the pathophysiology of hypercalcaemia of malignancy, focusing on the role of PTHrP before discussing further pathological and physiological processes in which PTHrP may be implicated, and the impact of this knowledge on the management of malignant disease.
bisphosphonates, bone metastasis, hypercalcaemia, parathyroid hormone-related protein
0936-6555
372-377
Bayne, M.C.
aa59681b-c38c-4371-8f2e-32bba0467658
Illidge, T.M.
43b02dd8-7761-4781-b10b-877e26222508
Bayne, M.C.
aa59681b-c38c-4371-8f2e-32bba0467658
Illidge, T.M.
43b02dd8-7761-4781-b10b-877e26222508

Bayne, M.C. and Illidge, T.M. (2001) Hypercalcaemia, parathyroid hormone-related protein and malignancy. Clinical Oncology, 13 (5), 372-377. (doi:10.1053/clon.2001.9293).

Record type: Article

Abstract

Hypercalcaemia is the most common serious metabolic complication of malignancy. Recent advances have significantly increased our understanding of the pathophysiology of hypercalcaemia of malignancy and revealed the importance of parathyroid hormone-related protein (PTHrP) in a wide range of physiological and pathological processes. This review examines the pathophysiology of hypercalcaemia of malignancy, focusing on the role of PTHrP before discussing further pathological and physiological processes in which PTHrP may be implicated, and the impact of this knowledge on the management of malignant disease.

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More information

Published date: 2001
Keywords: bisphosphonates, bone metastasis, hypercalcaemia, parathyroid hormone-related protein

Identifiers

Local EPrints ID: 26217
URI: http://eprints.soton.ac.uk/id/eprint/26217
ISSN: 0936-6555
PURE UUID: 00faab10-14d4-4de5-9449-3eb07135dc25

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Date deposited: 24 Apr 2006
Last modified: 15 Mar 2024 07:08

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Contributors

Author: M.C. Bayne
Author: T.M. Illidge

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