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Breakpoints of variant 9;22 translocations in chronic myeloid leukemia locate preferentially in the CG-richest regions of the genome

Breakpoints of variant 9;22 translocations in chronic myeloid leukemia locate preferentially in the CG-richest regions of the genome
Breakpoints of variant 9;22 translocations in chronic myeloid leukemia locate preferentially in the CG-richest regions of the genome
From 5% to 10% of 9;22 translocations in chronic myeloid leukemia (CML) are reported to occur in variant form, that is, with the involvement of other regions of the genome in 3-way or more rearrangements. The literature indicates that the alternative breakpoints are not distributed randomly in the genome but show hotspots. We present data on 289 unpublished cases of CML with variant 9;22 translocations having a total of 342 variant breakpoints, the largest independent series to date. We found that the distribution of breaks was in loose agreement with the literature but that some new hotspots were identified; furthermore, some published hotspots were not fully supported by our data. Moreover, when our 342 variant breakpoints were plotted against profiles of CG heterogeneity in the genome, a significant positive correlation between breakpoint locations and CG composition was observed. In an ancillary study, we compared the frequency of variant t(9;22) with that of variants of t(15;17) associated with acute promyelocytic leukemia (AML M3). We found that the frequency of the former, 9.3%, was significantly higher than that of the latter, 2.6%.
1098-2264
383-389
Fisher, A.M.
df7be148-7fe1-4dac-82af-af44890eebaa
Strike, P.
18228bfb-5099-4840-ab58-155f4b7d1b00
Scott, C.
2c763748-d634-401f-b8e6-62b5db6896b7
Moorman, A.V.
af5027f3-4927-4e62-b1be-ac4bdcf6cd8f
Fisher, A.M.
df7be148-7fe1-4dac-82af-af44890eebaa
Strike, P.
18228bfb-5099-4840-ab58-155f4b7d1b00
Scott, C.
2c763748-d634-401f-b8e6-62b5db6896b7
Moorman, A.V.
af5027f3-4927-4e62-b1be-ac4bdcf6cd8f

Fisher, A.M., Strike, P., Scott, C. and Moorman, A.V. (2005) Breakpoints of variant 9;22 translocations in chronic myeloid leukemia locate preferentially in the CG-richest regions of the genome. Genes, Chromosomes and Cancer, 43 (4), 383-389. (doi:10.1002/gcc.20196).

Record type: Article

Abstract

From 5% to 10% of 9;22 translocations in chronic myeloid leukemia (CML) are reported to occur in variant form, that is, with the involvement of other regions of the genome in 3-way or more rearrangements. The literature indicates that the alternative breakpoints are not distributed randomly in the genome but show hotspots. We present data on 289 unpublished cases of CML with variant 9;22 translocations having a total of 342 variant breakpoints, the largest independent series to date. We found that the distribution of breaks was in loose agreement with the literature but that some new hotspots were identified; furthermore, some published hotspots were not fully supported by our data. Moreover, when our 342 variant breakpoints were plotted against profiles of CG heterogeneity in the genome, a significant positive correlation between breakpoint locations and CG composition was observed. In an ancillary study, we compared the frequency of variant t(9;22) with that of variants of t(15;17) associated with acute promyelocytic leukemia (AML M3). We found that the frequency of the former, 9.3%, was significantly higher than that of the latter, 2.6%.

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Published date: 2005

Identifiers

Local EPrints ID: 26303
URI: http://eprints.soton.ac.uk/id/eprint/26303
ISSN: 1098-2264
PURE UUID: f6a86a11-8eba-4abf-a3ac-28e71ffee435

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Date deposited: 20 Apr 2006
Last modified: 15 Mar 2024 07:09

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Contributors

Author: A.M. Fisher
Author: P. Strike
Author: C. Scott
Author: A.V. Moorman

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