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Predicting Progression--ZAP-70 in CLL

Predicting Progression--ZAP-70 in CLL
Predicting Progression--ZAP-70 in CLL
The harder we look, the more we find. Diagnoses of chronic lymphocytic leukemia (CLL) are becoming more common because we are looking harder. With sensitive techniques, a monoclonal population of B lymphocytes that is indistinguishable from CLL cells may be found in the blood of 3.5 percent of persons older than 40 years of age. Even without such sophisticated methods, simple immunophenotyping, which is available to all, easily singles out CLL from the many other causes of slight lymphocytosis. Such a finding will never have clinical effects in most people — they will die with it rather than from it . . .
856-857
Hamblin, Terry J.
57389613-7900-48fd-b3e6-8ca8fbdceccb
Hamblin, Terry J.
57389613-7900-48fd-b3e6-8ca8fbdceccb

Hamblin, Terry J. (2004) Predicting Progression--ZAP-70 in CLL. New England Journal of Medicine, 351 (9), 856-857.

Record type: Article

Abstract

The harder we look, the more we find. Diagnoses of chronic lymphocytic leukemia (CLL) are becoming more common because we are looking harder. With sensitive techniques, a monoclonal population of B lymphocytes that is indistinguishable from CLL cells may be found in the blood of 3.5 percent of persons older than 40 years of age. Even without such sophisticated methods, simple immunophenotyping, which is available to all, easily singles out CLL from the many other causes of slight lymphocytosis. Such a finding will never have clinical effects in most people — they will die with it rather than from it . . .

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Published date: 2004
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Local EPrints ID: 26349
URI: http://eprints.soton.ac.uk/id/eprint/26349
PURE UUID: e3f2ce76-eab3-45bf-b2cc-cfbcb294f561

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Date deposited: 21 Apr 2006
Last modified: 22 Jul 2022 20:34

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Author: Terry J. Hamblin

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