Disproportionate alterations in body composition of large for gestational age neonates


Hammami, Mouhanad, Walters, Jocelyn, Hockman, Elaine M. and Koo, Winston W.K. (2001) Disproportionate alterations in body composition of large for gestational age neonates. Journal of Pediatrics, 138, (6), 817-821. (doi:10.1067/mpd.2001.114018).

Download

Full text not available from this repository.

Original Publication URL: http://dx.doi.org/10.1067/mpd.2001.114018

Description/Abstract

Objective: The objective was to compare dual-energy x-ray absorptiometry– measured body composition between large (LGA) and appropriate (AGA) birth weight for gestational age neonates.

Study design: LGA term infants (n = 47) with birth weights ≥4000 g were compared with 47 gestational age-matched AGA infants; 11 LGA infants were born to mothers with gestational (9) or pregestational diabetes (2). Dual-energy x-ray absorptiometry scans were performed at 1.8 ± 1.0 days after birth.

Results: Body weight and length were the dominant predictors of body composition in LGA and AGA neonates. However, LGA neonates had significantly (P < .001, all comparisons) higher absolute amounts of total body fat, lean body mass, and bone mineral content and had significantly (P < .001, all comparisons) higher proportions of total body fat and bone mineral content but lower lean body mass as a percent of body weight. The changes for total body fat and lean body mass as a percent of body weight were greatest (P < .001) in LGA infants whose mothers had impaired glucose tolerance.

Conclusion: LGA neonates have higher body fat and lower lean body mass than AGA infants. Impaired maternal glucose tolerance exaggerated these body composition changes.

Item Type: Article
Related URLs:
Subjects: R Medicine > RG Gynecology and obstetrics
Divisions: University Structure - Pre August 2011 > School of Medicine > Cancer Sciences
ePrint ID: 26353
Date Deposited: 24 Apr 2006
Last Modified: 27 Mar 2014 18:15
Contact Email Address: J.C.Walters@soton.ac.uk
URI: http://eprints.soton.ac.uk/id/eprint/26353

Actions (login required)

View Item View Item