The University of Southampton
University of Southampton Institutional Repository

Phase I study of Vinflunine administered as a 10-minute infusion on days 1 and 8 every 3 weeks

Phase I study of Vinflunine administered as a 10-minute infusion on days 1 and 8 every 3 weeks
Phase I study of Vinflunine administered as a 10-minute infusion on days 1 and 8 every 3 weeks
Vinflunine is a novel vinca alkaloid developed through the selective modification of vinorelbine using super-acidic chemistry. In preclinical testing, vinflunine demonstrated significantly enhanced anti-tumour activity in human tumour xenograft models when compared to its parent compound. A phase I study was conducted to evaluate the safety and toxicity of vinflunine administered as a 10 minute intravenous infusion on days 1 and 8 every three weeks. Sixteen patients with advanced solid tumours were treated. Two of four patients experienced dose limiting toxicities (DLT) at 190 mg/m2 and this was established as the maximum tolerated dose (MTD). At the MTD, the DLT of vinflunine consisted of constipation and neutropenia. Fatigue was notable but not dose limiting. No objective responses were observed. A dose of 170 mg/m2 given on a day 1 and 8 schedule every three weeks would be suitable for future studies.
vinflunine, phase I, safety, toxicity
0167-6997
223-231
Johnson, Peter
3f6068ce-171e-4c2c-aca9-dc9b6a37413f
Geldart, Thomas
d4abf5e9-c86e-485d-9a0d-e278020cbc2a
Fumoleau, Pierre
bfc22535-d29d-43c6-bf6f-de762884bc70
Pinel, Marie-Claire
0094d334-1425-4f06-880e-90f5d1e1bd81
Nguyen, Laurent
2b8f1de1-934f-4950-9fab-fc50cb0a2a6e
Judson, Ian
d1a59bc2-0042-40c1-a275-f1ab7a7069e0
Johnson, Peter
3f6068ce-171e-4c2c-aca9-dc9b6a37413f
Geldart, Thomas
d4abf5e9-c86e-485d-9a0d-e278020cbc2a
Fumoleau, Pierre
bfc22535-d29d-43c6-bf6f-de762884bc70
Pinel, Marie-Claire
0094d334-1425-4f06-880e-90f5d1e1bd81
Nguyen, Laurent
2b8f1de1-934f-4950-9fab-fc50cb0a2a6e
Judson, Ian
d1a59bc2-0042-40c1-a275-f1ab7a7069e0

Johnson, Peter, Geldart, Thomas, Fumoleau, Pierre, Pinel, Marie-Claire, Nguyen, Laurent and Judson, Ian (2005) Phase I study of Vinflunine administered as a 10-minute infusion on days 1 and 8 every 3 weeks. Investigational New Drugs, 24 (3), 223-231. (doi:10.1007/s10637-005-3902-0).

Record type: Article

Abstract

Vinflunine is a novel vinca alkaloid developed through the selective modification of vinorelbine using super-acidic chemistry. In preclinical testing, vinflunine demonstrated significantly enhanced anti-tumour activity in human tumour xenograft models when compared to its parent compound. A phase I study was conducted to evaluate the safety and toxicity of vinflunine administered as a 10 minute intravenous infusion on days 1 and 8 every three weeks. Sixteen patients with advanced solid tumours were treated. Two of four patients experienced dose limiting toxicities (DLT) at 190 mg/m2 and this was established as the maximum tolerated dose (MTD). At the MTD, the DLT of vinflunine consisted of constipation and neutropenia. Fatigue was notable but not dose limiting. No objective responses were observed. A dose of 170 mg/m2 given on a day 1 and 8 schedule every three weeks would be suitable for future studies.

This record has no associated files available for download.

More information

Published date: 2005
Keywords: vinflunine, phase I, safety, toxicity

Identifiers

Local EPrints ID: 26410
URI: http://eprints.soton.ac.uk/id/eprint/26410
ISSN: 0167-6997
PURE UUID: 66fb1d74-ee84-4eba-827f-64e8b5c518df
ORCID for Peter Johnson: ORCID iD orcid.org/0000-0003-2306-4974

Catalogue record

Date deposited: 07 Apr 2006
Last modified: 16 Mar 2024 02:59

Export record

Altmetrics

Contributors

Author: Peter Johnson ORCID iD
Author: Thomas Geldart
Author: Pierre Fumoleau
Author: Marie-Claire Pinel
Author: Laurent Nguyen
Author: Ian Judson

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×