High speed multi-frequency impedance analysis of single particles in a microfluidic cytometer using maximum length sequences
Sun, Tao, Holmes, David, Gawad, Shady, Green, Nicolas G and Morgan, Hywel (2007) High speed multi-frequency impedance analysis of single particles in a microfluidic cytometer using maximum length sequences. Lab On A Chip, DOI: 1
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Description/Abstract
A novel impedance spectroscopy technique has been developed for high speed single biological particle analysis. A microfluidic cytometer is used to measure the impedance of single micrometre sized latex particles at high speed across a range of frequencies. The setup uses a technique based on maximum length sequence (MLS) analysis, where the time-dependent response of the system is measured in the time domain and transformed into the impulse response using fast M-sequence transform (FMT). Finally fast Fourier transform (FFT) is applied to the impulse response to give the transfer-function of the system in the frequency domain. It is demonstrated that the MLS technique can give multi-frequency (broad-band) measurement in a short time period (ms). The impedance spectra of polystyrene micro-beads are measured at 512 evenly distributed frequencies over a range from 976.5625 Hz to 500 kHz. The spectral information for each bead is obtained in approximately 1 ms. Good agreement is shown between the MLS data and both circuit simulations and conventional AC single frequency measurements.
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Physical Sciences and Engineering > Electronics and Computer Science > NANO |
| Item ID: | 264155 |
| Date Deposited: | 11 Jun 2007 |
| Last Modified: | 21 Aug 2012 03:56 |
| Contributors: | Sun, Tao (Author) Holmes, David (Author) Gawad, Shady (Author) Green, Nicolas G (Author) Morgan, Hywel (Author) |
| Date: | 2007 |
| Status: | Published |
| Further Information: | Google Scholar |
| ISI Citation Count: | 37 |
| URI: | http://eprints.soton.ac.uk/id/eprint/264155 |
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