Micromachined glass apertures for artificial lipid bilayer formation in a microfluidic system


Sandison, M.E., Zagnoni, M., Abu-Hantash, M. and Morgan, H. (2007) Micromachined glass apertures for artificial lipid bilayer formation in a microfluidic system. Journal of Micromechanics and Microengineering, 17, S189-S196.

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Description/Abstract

The use of spark assisted chemical engraving (SACE) to produce glass apertures that are suitable for the formation of artificial bilayer lipid membranes is described. Prior to use, the glass apertures were rendered hydrophobic by a silanization process and were then incorporated into a simple microfluidic device. Successful bilayer lipid membrane (BLM) formation and the subsequent acquisition of single-channel recordings are demonstrated. Due to the simplicity and rapidity of the SACE process, these glass apertures could be easily integrated into an all-glass microfluidic system for BLM formation.

Item Type: Article
Divisions: Faculty of Physical Sciences and Engineering > Electronics and Computer Science > NANO
ePrint ID: 264501
Date Deposited: 14 Sep 2007
Last Modified: 27 Mar 2014 20:08
Further Information:Google Scholar
ISI Citation Count:13
URI: http://eprints.soton.ac.uk/id/eprint/264501

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