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Mcl-1

Mcl-1
Mcl-1
Mcl-1 is a Bcl-2 family protein which can act as an apical molecule in apoptosis control, promoting cell survival by interfering at an early stage in a cascade of events leading to release of cytochrome c from mitochondria. Mcl-1 has a short half life and is a highly regulated protein, induced by a wide range of survival signals and also rapidly down regulated during apoptosis. Mcl-1 can also readily be cleaved by caspases during apoptosis to produce a cell death promoting molecule. The multiple levels of control of Mcl-1 expression suggest that Mcl-1 plays a critical role in controlling life and death decisions in response to rapidly changing environmental cues and Mcl-1 is required for embryonic development and the function of the immune system. Expression of Mcl-1 may be useful in informing decision making in the treatment of various cancers, and countering Mcl-1 function may be an attractive therapeutic strategy in malignancy, inflammatory conditions and infectious disease where Mcl-1 may play a major role in suppressing apoptosis.
apoptosis, Bcl-2, regulation, caspase, structure
1357-2725
267-271
Michels, Jorg
79d364fb-199d-4751-ab23-cd31b1a8cda4
Johnson, Peter W.M.
1a86c9a9-25b4-4529-9353-d14fd062d63b
Packham, Graham
fdabe56f-2c58-469c-aadf-38878f233394
Michels, Jorg
79d364fb-199d-4751-ab23-cd31b1a8cda4
Johnson, Peter W.M.
1a86c9a9-25b4-4529-9353-d14fd062d63b
Packham, Graham
fdabe56f-2c58-469c-aadf-38878f233394

Michels, Jorg, Johnson, Peter W.M. and Packham, Graham (2005) Mcl-1. International Journal of Biochemistry & Cell Biology, 37 (2), 267-271. (doi:10.1016/j.biocel.2004.04.007).

Record type: Article

Abstract

Mcl-1 is a Bcl-2 family protein which can act as an apical molecule in apoptosis control, promoting cell survival by interfering at an early stage in a cascade of events leading to release of cytochrome c from mitochondria. Mcl-1 has a short half life and is a highly regulated protein, induced by a wide range of survival signals and also rapidly down regulated during apoptosis. Mcl-1 can also readily be cleaved by caspases during apoptosis to produce a cell death promoting molecule. The multiple levels of control of Mcl-1 expression suggest that Mcl-1 plays a critical role in controlling life and death decisions in response to rapidly changing environmental cues and Mcl-1 is required for embryonic development and the function of the immune system. Expression of Mcl-1 may be useful in informing decision making in the treatment of various cancers, and countering Mcl-1 function may be an attractive therapeutic strategy in malignancy, inflammatory conditions and infectious disease where Mcl-1 may play a major role in suppressing apoptosis.

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More information

Published date: 2005
Keywords: apoptosis, Bcl-2, regulation, caspase, structure

Identifiers

Local EPrints ID: 26482
URI: http://eprints.soton.ac.uk/id/eprint/26482
ISSN: 1357-2725
PURE UUID: 6211d8f9-3738-4565-904b-0fb7a702ba0f
ORCID for Graham Packham: ORCID iD orcid.org/0000-0002-9232-5691

Catalogue record

Date deposited: 12 Apr 2006
Last modified: 16 Mar 2024 03:14

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Contributors

Author: Jorg Michels
Author: Peter W.M. Johnson
Author: Graham Packham ORCID iD

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