Karyotype and age in acute myeloid leukemia. Are they linked?
Karyotype and age in acute myeloid leukemia. Are they linked?
A novel hierarchical cytogenetic classification for acute myeloid leukemia (AML) has been developed. Patients with successful cytogenetics and a diagnosis of AML were categorized into four mutually exclusive karyotype groups: normal, translocation, deletion and trisomy. Patients with more than one chromosomal abnormality were classified using the hierarchy: established translocation>established deletion>established trisomy>non-established translocation>non-established deletion>non-established trisomy. A total of 593 AML patients from a large population-based case-control study of acute leukemia were classified according to their diagnostic karyotype. The four karyotype groups showed different age distributions. Overall the frequency of patients increased with age as did the frequency of patients with a deletion, trisomy or normal karyotype. Although the increase of patients with age was much sharper for patients with a deletion. In contrast, the distribution of patients with a translocation was roughly constant with age. We concluded that there was a link between karyotype and the age of the patient at diagnosis. Furthermore, two karyotype groups, translocations and deletions, may define disease entities with different etiologies. This novel cytogenetic classification will allow other studies to examine whether AML cases with very different types of chromosomal abnormality have the same etiology.
155-161
Moorman, Anthony V.
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Roman, Eve
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Willett, Eleanor V.
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Dovey, Gareth J.
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Cartwright, Raymond A.
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Morgan, Gareth J.
d285dcf8-ac2c-4fe0-acf9-4787eb025939
2001
Moorman, Anthony V.
e4ced178-ee03-47ef-bc5e-25d8453951d5
Roman, Eve
2c1bb28b-5853-4f8d-86bb-4a2780c6dde0
Willett, Eleanor V.
3ef8c008-ab68-4f7d-bbf9-40b3654e85ea
Dovey, Gareth J.
9407ab24-3475-4691-8476-9cedff7026b6
Cartwright, Raymond A.
c3120d6e-bcfc-4603-92b6-68407baee942
Morgan, Gareth J.
d285dcf8-ac2c-4fe0-acf9-4787eb025939
Moorman, Anthony V., Roman, Eve, Willett, Eleanor V., Dovey, Gareth J., Cartwright, Raymond A. and Morgan, Gareth J.
(2001)
Karyotype and age in acute myeloid leukemia. Are they linked?
Cancer Genetics and Cytogenetics, 126 (2), .
(doi:10.1016/S0165-4608(00)00414-3).
Abstract
A novel hierarchical cytogenetic classification for acute myeloid leukemia (AML) has been developed. Patients with successful cytogenetics and a diagnosis of AML were categorized into four mutually exclusive karyotype groups: normal, translocation, deletion and trisomy. Patients with more than one chromosomal abnormality were classified using the hierarchy: established translocation>established deletion>established trisomy>non-established translocation>non-established deletion>non-established trisomy. A total of 593 AML patients from a large population-based case-control study of acute leukemia were classified according to their diagnostic karyotype. The four karyotype groups showed different age distributions. Overall the frequency of patients increased with age as did the frequency of patients with a deletion, trisomy or normal karyotype. Although the increase of patients with age was much sharper for patients with a deletion. In contrast, the distribution of patients with a translocation was roughly constant with age. We concluded that there was a link between karyotype and the age of the patient at diagnosis. Furthermore, two karyotype groups, translocations and deletions, may define disease entities with different etiologies. This novel cytogenetic classification will allow other studies to examine whether AML cases with very different types of chromosomal abnormality have the same etiology.
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Published date: 2001
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Local EPrints ID: 26491
URI: http://eprints.soton.ac.uk/id/eprint/26491
ISSN: 0165-4608
PURE UUID: 13f31220-086e-4c42-ba74-e38ea1863c67
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Date deposited: 12 Apr 2006
Last modified: 15 Mar 2024 07:11
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Author:
Anthony V. Moorman
Author:
Eve Roman
Author:
Eleanor V. Willett
Author:
Gareth J. Dovey
Author:
Raymond A. Cartwright
Author:
Gareth J. Morgan
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