Smoking and the risk of acute myeloid leukaemia in cytogenetic subgroups
Moorman, A.V., Roman, E., Cartwright, R.A. and Morgan, G.J. (2002) Smoking and the risk of acute myeloid leukaemia in cytogenetic subgroups. British Journal of Cancer, 86, (1), 60-62. (doi:10.1038/sj/bjc/6600010)
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Official URL: http://dx.doi.org/10.1038/sj/bjc/6600010
Description/Abstract
Cytogenetically-defined subgroups of acute myeloid leukaemia have distinct biologies, clinical features and outcomes. Evidence from therapy-related leukaemia suggests that chromosomal abnormalities are also markers of exposure. Our results suggest that the smoking-associated risk for acute myeloid leukaemia is restricted to the t(8;21)(q22;q22) subgroup. This supports the hypothesis that distinct cytogenetic subgroups of acute myeloid leukaemia have separate aetiologies.
| Item Type: | Article |
|---|---|
| ISSN: | 0007-0920 (print) |
| Uncontrolled Keywords: | cytogenetics, chromosomal abnormalities, tobacco smoke, acute myeloid leukaemia, aetiology |
| Related URLs: | http://www.ncbi.nlm.nih.gov/en...s=11857012 http://www.nature.com/bjc/jour...0010a.html http://dx.doi.org/10.1038/sj/bjc/6600010 |
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Cancer Sciences |
| ePrint ID: | 26495 |
| URI: | http://eprints.soton.ac.uk/id/eprint/26495 |
| Deposited On: | 12 Apr 2006 |
| Last Modified: | 01 Jun 2011 09:50 |
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