Smoking and the risk of acute myeloid leukaemia in cytogenetic subgroups

Moorman, A.V., Roman, E., Cartwright, R.A. and Morgan, G.J. (2002) Smoking and the risk of acute myeloid leukaemia in cytogenetic subgroups. British Journal of Cancer, 86, (1), 60-62. (doi:10.1038/sj/bjc/6600010).

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Original Publication URL: http://dx.doi.org/10.1038/sj/bjc/6600010

Description/Abstract

Cytogenetically-defined subgroups of acute myeloid leukaemia have distinct biologies, clinical features and outcomes. Evidence from therapy-related leukaemia suggests that chromosomal abnormalities are also markers of exposure. Our results suggest that the smoking-associated risk for acute myeloid leukaemia is restricted to the t(8;21)(q22;q22) subgroup. This supports the hypothesis that distinct cytogenetic subgroups of acute myeloid leukaemia have separate aetiologies.

Item Type:	Article
ISSNs:	0007-0920 (print)
Related URLs:	http://www.ncbi.nlm.nih.gov/en...s=11857012 http://www.nature.com/bjc/jour...0010a.html http://dx.doi.org/10.1038/sj/bjc/6600010
Keywords:	cytogenetics, chromosomal abnormalities, tobacco smoke, acute myeloid leukaemia, aetiology
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions:	University Structure - Pre August 2011 > School of Medicine > Cancer Sciences
Item ID:	26495
Date Deposited:	12 Apr 2006
Last Modified:	01 Jun 2011 08:50
Contributors:	Moorman, A.V. (Author) Roman, E. (Author) Cartwright, R.A. (Author) Morgan, G.J. (Author)
Date:	2002
Status:	Published
Contact Email Address:	avm@soton.ac.uk
URI:	http://eprints.soton.ac.uk/id/eprint/26495

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