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Outcome heterogeneity in childhood high-hyperdiploid acute lymphoblastic leukemia

Outcome heterogeneity in childhood high-hyperdiploid acute lymphoblastic leukemia
Outcome heterogeneity in childhood high-hyperdiploid acute lymphoblastic leukemia
High hyperdiploidy (HeH) (51 to 65 chromosomes) is found in one third of children with acute lymphoblastic leukemia and is associated with a good prognosis. Cytogenetic features may further refine this prognosis and identify patients with a poor outcome. We examined the effect of sex, age, individual trisomies, modal number, and structural abnormalities on survival among 700 children with HeH. Univariate analysis showed that age. sex, +4, +10, +18, and a high modal number were associated with survival. Multivariate analysis however, revealed that only age, sex, +4, and +18 were independent indicators. Hazard scores for predicting relapse and mortality were constructed. Three risk groups with 5-year event-free survival (EFS) rates of 86%, 75%, and 50% (P < .0001) were identified. The high-risk group comprised boys older than 9 years, boys aged 1 through 9 years without +18, and girls older than 9 years without +18, while girls aged 1 through 9 years with +18 had the best EFS. In terms of mortality, those younger than age 10 years with both +4 and +18 had an improved survival (96% vs 84% at 5 years, P < .0001). These findings confirm that the outcome of children with HeH is heterogeneous and that specific trisomies can identify patients with the greatest and least risk of treatment failure
0006-4971
2756-2762
Moorman, Anthony V.
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Richards, Sue M.
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Martineau, Mary
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Cheung, Kan Luk
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Robinson, Hazel M.
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Jalali, G. Reza
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Broadfield, Zoë J.
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Harris, Rachel L.
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Taylor, Kerry E.
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Gibson, Brenda E.
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Hann, Ian M.
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Hill, Frank G.H.
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Kinsey, Sally E.
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Eden, Tim O.B.
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Mitchell, Christopher D.
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Harrison, Christine J.
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Moorman, Anthony V.
e4ced178-ee03-47ef-bc5e-25d8453951d5
Richards, Sue M.
d3a46ce3-0633-4781-812e-fa9faa77cad5
Martineau, Mary
6cc6f57f-7b57-4583-81eb-17dac737e35c
Cheung, Kan Luk
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Robinson, Hazel M.
c406aa02-ca17-4ba1-9aa4-24bab6415fc0
Jalali, G. Reza
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Broadfield, Zoë J.
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Harris, Rachel L.
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Taylor, Kerry E.
f4e3b187-d274-48b1-aca8-661a12741666
Gibson, Brenda E.
d6f77b81-a6aa-41c4-b089-dfcdba8a549f
Hann, Ian M.
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Hill, Frank G.H.
15e6afe6-de72-4b35-9398-d2d63fa50f46
Kinsey, Sally E.
ae9c91c4-cb85-4da4-a8e6-d01409ad4656
Eden, Tim O.B.
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Mitchell, Christopher D.
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Harrison, Christine J.
52da7673-509c-4b88-b92e-0c021c9c7d3e

Moorman, Anthony V., Richards, Sue M., Martineau, Mary, Cheung, Kan Luk, Robinson, Hazel M., Jalali, G. Reza, Broadfield, Zoë J., Harris, Rachel L., Taylor, Kerry E., Gibson, Brenda E., Hann, Ian M., Hill, Frank G.H., Kinsey, Sally E., Eden, Tim O.B., Mitchell, Christopher D. and Harrison, Christine J. (2003) Outcome heterogeneity in childhood high-hyperdiploid acute lymphoblastic leukemia. Blood, 102 (8), 2756-2762. (doi:10.1182/blood-2003-04-1128).

Record type: Article

Abstract

High hyperdiploidy (HeH) (51 to 65 chromosomes) is found in one third of children with acute lymphoblastic leukemia and is associated with a good prognosis. Cytogenetic features may further refine this prognosis and identify patients with a poor outcome. We examined the effect of sex, age, individual trisomies, modal number, and structural abnormalities on survival among 700 children with HeH. Univariate analysis showed that age. sex, +4, +10, +18, and a high modal number were associated with survival. Multivariate analysis however, revealed that only age, sex, +4, and +18 were independent indicators. Hazard scores for predicting relapse and mortality were constructed. Three risk groups with 5-year event-free survival (EFS) rates of 86%, 75%, and 50% (P < .0001) were identified. The high-risk group comprised boys older than 9 years, boys aged 1 through 9 years without +18, and girls older than 9 years without +18, while girls aged 1 through 9 years with +18 had the best EFS. In terms of mortality, those younger than age 10 years with both +4 and +18 had an improved survival (96% vs 84% at 5 years, P < .0001). These findings confirm that the outcome of children with HeH is heterogeneous and that specific trisomies can identify patients with the greatest and least risk of treatment failure

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More information

Published date: 2003
Additional Information: United Kingdom Medical Research Council's Childhood Leukaemia Working Party

Identifiers

Local EPrints ID: 26496
URI: http://eprints.soton.ac.uk/id/eprint/26496
ISSN: 0006-4971
PURE UUID: 9946fbaf-f745-4d86-921f-7a4e788fce60

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Date deposited: 19 Apr 2006
Last modified: 15 Mar 2024 07:11

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Contributors

Author: Anthony V. Moorman
Author: Sue M. Richards
Author: Mary Martineau
Author: Kan Luk Cheung
Author: Hazel M. Robinson
Author: G. Reza Jalali
Author: Zoë J. Broadfield
Author: Rachel L. Harris
Author: Kerry E. Taylor
Author: Brenda E. Gibson
Author: Ian M. Hann
Author: Frank G.H. Hill
Author: Sally E. Kinsey
Author: Tim O.B. Eden
Author: Christopher D. Mitchell
Author: Christine J. Harrison

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