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No prognostic effect of additional chromosomal abnormalities in children with acute lymphoblastic leukemia and 11q23 abnormalities

No prognostic effect of additional chromosomal abnormalities in children with acute lymphoblastic leukemia and 11q23 abnormalities
No prognostic effect of additional chromosomal abnormalities in children with acute lymphoblastic leukemia and 11q23 abnormalities
This study characterized the additional chromosomal abnormalities (ACA) associated with 11q23 rearrangements in 450 infants and children with acute lymphoblastic leukemia (ALL) and examined the impact of these ACA on survival. Overall, 213 (47%) cases had ACA but the incidence varied according to patient age and 11q23 subgroup. Infants and patients with t(4;11)(q21;q23) had the lowest incidence of ACA (50/182 (27%) and 57/216 (26%) respectively), whereas patients with del(11)(q23) had the highest incidence (66/93 (71%)). Del(11)(q23) abnormalities were heterogeneous and occasionally secondary to t(9;22)(q34;q11.2). Thus, patients with del(11)(q23) comprised a separate biological entity, which was clearly distinct from those with an 11q23 translocation. The most frequent specific ACA were trisomy X (n=38), abnormal 12p (n=32), abnormal 9p (n=28) and del(6q) (n=19). The presence of ACA did not change the 5 year event-free survival estimates among children (56% (95% CI 46?65%) vs 62% (54?69%)) or infants (22% (15?29%) vs 18% (9?29%)), nor when the different 11q23 subgroups were analyzed separately. This study has conclusively demonstrated that there is no prognostic effect of secondary chromosomal changes in association with 11q23 abnormalities in childhood ALL. However, characterization of these ACA is important to determine their potential role in initiation of MLL driven leukemogenesis.
acute lymphoblastic leukemia, childhood, infant, cytogenetics, 11q23, MLL
0887-6924
557-563
Moorman, A.V.
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Raimondi, S.C.
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Pui, C.H.
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Baruchel, A.
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Biondi, A.
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Carroll, A.J.
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Forestier, E.
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Gaynon, P.S.
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Harbott, J.
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Harms, D.O.
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Heerema, N.
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Pieters, R.
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Schrappe, M.
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Silverman, L.B.
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Vilmer, E.
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Harrison, C.J.
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Moorman, A.V.
af5027f3-4927-4e62-b1be-ac4bdcf6cd8f
Raimondi, S.C.
832b2c10-be4d-4428-a81d-e82005d6659d
Pui, C.H.
328aaa19-53dd-4e8e-858b-ab5160be1d7d
Baruchel, A.
968335cb-8aee-43b5-a164-6b6838117fa8
Biondi, A.
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Carroll, A.J.
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Forestier, E.
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Gaynon, P.S.
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Harbott, J.
c9419ae3-be8f-4144-9e47-c85a5c1524b6
Harms, D.O.
ef009a28-f112-4f4c-abc3-d82651afaa1e
Heerema, N.
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Pieters, R.
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Schrappe, M.
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Silverman, L.B.
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Vilmer, E.
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Harrison, C.J.
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Moorman, A.V., Raimondi, S.C., Pui, C.H., Baruchel, A., Biondi, A., Carroll, A.J., Forestier, E., Gaynon, P.S., Harbott, J., Harms, D.O., Heerema, N., Pieters, R., Schrappe, M., Silverman, L.B., Vilmer, E. and Harrison, C.J. (2005) No prognostic effect of additional chromosomal abnormalities in children with acute lymphoblastic leukemia and 11q23 abnormalities. Leukemia, 19 (4), 557-563. (doi:10.1038/sj.leu.2403695).

Record type: Article

Abstract

This study characterized the additional chromosomal abnormalities (ACA) associated with 11q23 rearrangements in 450 infants and children with acute lymphoblastic leukemia (ALL) and examined the impact of these ACA on survival. Overall, 213 (47%) cases had ACA but the incidence varied according to patient age and 11q23 subgroup. Infants and patients with t(4;11)(q21;q23) had the lowest incidence of ACA (50/182 (27%) and 57/216 (26%) respectively), whereas patients with del(11)(q23) had the highest incidence (66/93 (71%)). Del(11)(q23) abnormalities were heterogeneous and occasionally secondary to t(9;22)(q34;q11.2). Thus, patients with del(11)(q23) comprised a separate biological entity, which was clearly distinct from those with an 11q23 translocation. The most frequent specific ACA were trisomy X (n=38), abnormal 12p (n=32), abnormal 9p (n=28) and del(6q) (n=19). The presence of ACA did not change the 5 year event-free survival estimates among children (56% (95% CI 46?65%) vs 62% (54?69%)) or infants (22% (15?29%) vs 18% (9?29%)), nor when the different 11q23 subgroups were analyzed separately. This study has conclusively demonstrated that there is no prognostic effect of secondary chromosomal changes in association with 11q23 abnormalities in childhood ALL. However, characterization of these ACA is important to determine their potential role in initiation of MLL driven leukemogenesis.

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More information

Published date: 2005
Additional Information: Original manuscript, childood all
Keywords: acute lymphoblastic leukemia, childhood, infant, cytogenetics, 11q23, MLL

Identifiers

Local EPrints ID: 26497
URI: http://eprints.soton.ac.uk/id/eprint/26497
ISSN: 0887-6924
PURE UUID: e675d99e-ab09-49b1-98ca-da9721f12e70

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Date deposited: 10 Apr 2006
Last modified: 15 Mar 2024 07:11

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Contributors

Author: A.V. Moorman
Author: S.C. Raimondi
Author: C.H. Pui
Author: A. Baruchel
Author: A. Biondi
Author: A.J. Carroll
Author: E. Forestier
Author: P.S. Gaynon
Author: J. Harbott
Author: D.O. Harms
Author: N. Heerema
Author: R. Pieters
Author: M. Schrappe
Author: L.B. Silverman
Author: E. Vilmer
Author: C.J. Harrison

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