Doping of carbon nanotubes with nitrogen improves protein coverage whilst retaining correct conformation
Burch, Hilary J., Antoranz Contera, Sonia, de Planque, Maurits R.R., Grobert, Nicole and Ryan, John F. (2008) Doping of carbon nanotubes with nitrogen improves protein coverage whilst retaining correct conformation. Nanotechnology, 19, (38), 384001. (doi:10.1088/0957-4484/19/38/384001).
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Description/Abstract
Relevant parameters for non-covalent protein functionalization of carbon nanotubes are explored. Multiwalled carbon nanotubes are carboxylated and functionalized with metalloproteins. Using atomic force microscopy (AFM) we quantitatively determine that coverage with nitrogen-doped multiwalled carbon nanotubes is superior compared to coverage with un-doped multiwalled carbon nanotubes, due to enhanced carboxylation. Conformational analysis using a combination of AFM, antibody binding assays, circular dichroism and UV–visible spectroscopy demonstrates that the metalloproteins retain their native structure when adsorbed to nitrogen-doped multiwalled carbon nanotubes irrespective of their size, charge or folding motif.
| Item Type: | Article |
|---|---|
| ISSNs: | 0957-4484 |
| Divisions: | Faculty of Physical Sciences and Engineering > Electronics and Computer Science > NANO |
| Item ID: | 265230 |
| Date Deposited: | 29 Feb 2008 15:42 |
| Last Modified: | 09 May 2013 13:33 |
| Contributors: | Burch, Hilary J. (Author) Antoranz Contera, Sonia (Author) de Planque, Maurits R.R. (Author) Grobert, Nicole (Author) Ryan, John F. (Author) |
| Date: | 12 August 2008 |
| Status: | Published |
| Further Information: | Google Scholar |
| ISI Citation Count: | 3 |
| URI: | http://eprints.soton.ac.uk/id/eprint/265230 |
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