BAG-1 in carcinogenesis

Sharp, Adam, Crabb, Simon J., Cutress, Ramsey I., Brimmell, Matthew, Wang, Xiu-hong, Packham, Graham and Townsend, Paul A. (2004) BAG-1 in carcinogenesis. Expert Reviews in Molecular Medicine, 6 (7), 1-15. (doi:10.1017/S1462399404007537). (PMID:15033003)

Abstract

BAG-1 is a multifunctional protein that exists as several differentially localised and functionally distinct isoforms. BAG-1 isoforms interact with a diverse array of molecular targets and regulate a wide range of cellular processes, including proliferation, survival, transcription, apoptosis, metastasis and motility. The BAG domain of BAG-1 interacts with chaperone molecules and this is considered important for many BAG-1 functions. The ability of BAG-1 to regulate such a wide variety of cellular processes suggests it might play an important role in many cancer types. For example, regulation of nuclear hormone receptor function and susceptibility to apoptosis might have a major impact on cancer development, progression and response to therapy. There is also increasing evidence that BAG-1 expression is altered in a variety of human malignancies relative to normal cells, and with further understanding of BAG-1 function it might become a powerful prognostic/predictive marker in human cancer. This review describes the structure and function of BAG-1 isoforms and the potential clinical implications of their expression in tumour cells.

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Contributors

Author: Simon J. Crabb

Author: Graham Packham

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