DNA vaccination: a potential weapon against infection and cancer


Stevenson, F.K. and Rosenberg, W. (2001) DNA vaccination: a potential weapon against infection and cancer. Vox Sanguinis, 80, (1), 12-18. (doi:10.1046/j.1423-0410.2001.00009.x).

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Description/Abstract

DNA vaccination is a novel approach for inducing immunity against target antigens. It provides a direct link between identification of genes encoding these antigens and incorporation of the gene sequences into a vaccine vehicle. Identification of candidate genes is proceeding very rapidly both for infectious organisms and for cancer cells. One advantage is that DNA appears to activate all pathways of immunity, especially cytotoxic T-cell responses, which have been difficult to induce with protein vaccines. For viruses, including those which have caused problems for blood transfusion, DNA vaccination could be used for prevention. However, for chronic infection, or for cancer, vaccination will be performed in a therapeutic setting. For this situation, it is probable that immune-activating sequences will have to be included in the vaccine. The ease of manipulation of gene sequences, together with the increasing knowledge of the operation of the immune system, means that we now have the tools to take vaccines into the next exciting stage of development.

Item Type: Article
Related URLs:
Subjects: R Medicine > RB Pathology
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Q Science > QH Natural history > QH426 Genetics
Divisions: University Structure - Pre August 2011 > School of Medicine > Cancer Sciences
University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair
ePrint ID: 26613
Date Deposited: 24 Apr 2006
Last Modified: 27 Mar 2014 18:15
Contact Email Address: fs@soton.ac.uk
URI: http://eprints.soton.ac.uk/id/eprint/26613

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