DNA fusion vaccines against B-cell tumors
Zhu, Delin, Rice, Jason, Savelyeva, Natalia and Stevenson, Freda K. (2001) DNA fusion vaccines against B-cell tumors. Trends in Molecular Medicine, 7, (12), 566-572. (doi:10.1016/S1471-4914(01)02126-8).
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Description/Abstract
DNA vaccination is currently being explored as a potential strategy for combatting cancer. However, tumor antigens are often weak and the immune system of patients may be compromised. For B-cell tumors, immunoglobulin idiotypic antigens provide defined targets but are poorly immunogenic. Fusion of a sequence derived from tetanus toxin to the genes encoding idiotypic determinants has proved highly effective in activating protective anti-tumor immunity. DNA fusion vaccines containing immuno-enhancing sequences can augment and direct immune attack on a range of target antigens. Gene-based fusion vaccines offer ease of manipulation and flexible design to activate effective attack on cancer.
| Item Type: | Article |
|---|---|
| Additional Information: | Review Article |
| ISSNs: | 1471-4914 (print) |
| Related URLs: | |
| Keywords: | DNA vaccine, tetanus toxin, fusion vaccine, B-cell tumor, lymphoma, myeloma |
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Cancer Sciences |
| Item ID: | 26675 |
| Date Deposited: | 24 Apr 2006 |
| Last Modified: | 01 Jun 2011 06:28 |
| Contributors: | Zhu, Delin (Author) Rice, Jason (Author) Savelyeva, Natalia (Author) Stevenson, Freda K. (Author) |
| Date: | 2001 |
| Additional Information: | Review Article |
| Status: | Published |
| Contact Email Address: | dz1@soton.ac.uk |
| URI: | http://eprints.soton.ac.uk/id/eprint/26675 |
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