DNA fusion vaccines against B-cell tumors
Zhu, Delin, Rice, Jason, Savelyeva, Natalia and Stevenson, Freda K. (2001) DNA fusion vaccines against B-cell tumors. Trends in Molecular Medicine, 7, (12), 566-572. (doi:10.1016/S1471-4914(01)02126-8).
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DNA vaccination is currently being explored as a potential strategy for combatting cancer. However, tumor antigens are often weak and the immune system of patients may be compromised. For B-cell tumors, immunoglobulin idiotypic antigens provide defined targets but are poorly immunogenic. Fusion of a sequence derived from tetanus toxin to the genes encoding idiotypic determinants has proved highly effective in activating protective anti-tumor immunity. DNA fusion vaccines containing immuno-enhancing sequences can augment and direct immune attack on a range of target antigens. Gene-based fusion vaccines offer ease of manipulation and flexible design to activate effective attack on cancer.
|Digital Object Identifier (DOI):||doi:10.1016/S1471-4914(01)02126-8|
|Additional Information:||Review Article|
|Keywords:||DNA vaccine, tetanus toxin, fusion vaccine, B-cell tumor, lymphoma, myeloma|
|Subjects:||R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)|
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Cancer Sciences
|Date Deposited:||24 Apr 2006|
|Last Modified:||06 Aug 2015 02:27|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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