DNA fusion vaccines against B-cell tumors

Zhu, Delin, Rice, Jason, Savelyeva, Natalia and Stevenson, Freda K. (2001) DNA fusion vaccines against B-cell tumors. Trends in Molecular Medicine, 7, (12), 566-572. (doi:10.1016/S1471-4914(01)02126-8).


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DNA vaccination is currently being explored as a potential strategy for combatting cancer. However, tumor antigens are often weak and the immune system of patients may be compromised. For B-cell tumors, immunoglobulin idiotypic antigens provide defined targets but are poorly immunogenic. Fusion of a sequence derived from tetanus toxin to the genes encoding idiotypic determinants has proved highly effective in activating protective anti-tumor immunity. DNA fusion vaccines containing immuno-enhancing sequences can augment and direct immune attack on a range of target antigens. Gene-based fusion vaccines offer ease of manipulation and flexible design to activate effective attack on cancer.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/S1471-4914(01)02126-8
Additional Information: Review Article
ISSNs: 1471-4914 (print)
Related URLs:
Keywords: DNA vaccine, tetanus toxin, fusion vaccine, B-cell tumor, lymphoma, myeloma
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions : University Structure - Pre August 2011 > School of Medicine > Cancer Sciences
ePrint ID: 26675
Accepted Date and Publication Date:
Date Deposited: 24 Apr 2006
Last Modified: 31 Mar 2016 11:49
URI: http://eprints.soton.ac.uk/id/eprint/26675

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