Patterns of somatic mutations in VH genes reveal pathways of clonal transformation from MGUS to multiple myeloma
Zojer, Niklas, Ludwig, Heinz, Fiegl, Michael, Stevenson, Freda K. and Sahota, Surinder S. (2003) Patterns of somatic mutations in VH genes reveal pathways of clonal transformation from MGUS to multiple myeloma. Blood, 101, (10), 4137-4139. (doi:10.1182/blood-2002-09-2825).
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Description/Abstract
Monoclonal gammopathy of undetermined significance (MGUS) can transform to multiple myeloma (MM). In myeloma, mutated VH genes with sequence homogeneity reveal a postfollicular origin. Previously, some MGUS cases showed mutated VH genes with intraclonal variation, indicating an earlier stage of arrest. We investigated progression from 2 of 2 MGUS to MM, in which VH genes confirmed clonal evolution. In one MGUS case, intraclonal heterogeneity was evident, and transformation to myeloma occurred rapidly with apparent homogeneity in the emergent clone. However, residual MGUS-derived sequences were detectable at this time. Heterogeneity in MGUS does not associate with benign disease, but it indicates an origin from a tumorigenic cell, most likely surface immunoglobulin+, undergoing somatic mutation. The remaining case displayed intraclonal homogeneity at the MGUS stage, conceivably resulting from a self-cloning outgrowth from MGUS with heterogeneity. Transformation can occur at either MGUS stage, but it involves a single cell in which somatic mutation is then silent.
| Item Type: | Article |
|---|---|
| Additional Information: | Neoplasia, brief report |
| ISSNs: | 0006-4971 (print) |
| Related URLs: | |
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) Q Science > QH Natural history > QH426 Genetics |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Cancer Sciences |
| Item ID: | 26681 |
| Date Deposited: | 24 Apr 2006 |
| Last Modified: | 02 Mar 2012 12:46 |
| Contributors: | Zojer, Niklas (Author) Ludwig, Heinz (Author) Fiegl, Michael (Author) Stevenson, Freda K. (Author) Sahota, Surinder S. (Author) |
| Date: | 2003 |
| Additional Information: | Neoplasia, brief report |
| Status: | Published |
| Contact Email Address: | fs@soton.ac.uk |
| URI: | http://eprints.soton.ac.uk/id/eprint/26681 |
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