Signal transduction via the NF-κB pathway: a targeted treatment modality for infection, inflammation and repair


Ali, Shakir and Mann, Derek A. (2004) Signal transduction via the NF-κB pathway: a targeted treatment modality for infection, inflammation and repair. Cell Biochemistry and Function, 22, (2), 67-79. (doi:10.1002/cbf.1082).

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Original Publication URL: http://dx.doi.org/10.1002/cbf.1082

Description/Abstract

Activation of transcription factors plays a pivotal role in many signal transduction pathways. Of particular interest is NF-B, which is present in the cytoplasm in an inactive form, where it can be activated in response to many different stress conditions such as infection, inflammation, heat shock etc. It has also been associated with apoptosis and tissue repair. Modulation of signal transduction events that mediate activation of NF-B seems to have a great potential in not only treating many disease conditions, but also in tissue repair.

The present review article is an attempt to put together many different conditions where the NF-B activation pathway appears to be crucial in transducing signals under stress conditions, and to explore the possibility of its modulation as a targeted treatment modality.

Item Type: Article
Additional Information: Review article
ISSNs: 0263-6484 (print)
Related URLs:
Subjects: Q Science > QR Microbiology > QR180 Immunology
Q Science > QP Physiology
Q Science > QH Natural history > QH426 Genetics
Divisions: University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair
ePrint ID: 26905
Date Deposited: 25 Apr 2006
Last Modified: 27 Mar 2014 18:15
Contact Email Address: dam2@soton.ac.uk)
URI: http://eprints.soton.ac.uk/id/eprint/26905

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