The contribution of transforming growth factor-ß and epidermal growth factor signalling to airway remodelling in chronic asthma
Boxall, C., Holgate, S.T. and Davies, D.E. (2006) The contribution of transforming growth factor-ß and epidermal growth factor signalling to airway remodelling in chronic asthma. European Respiratory Journal, 27, (1), 208-229. (doi:10.1183/09031936.06.00130004).
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Asthma is increasing in prevalence in the developing world, affecting 10% of the world’s population. It is characterised by chronic lung inflammation and airway remodelling associated with wheezing, shortness of breath, acute bronchial hyperresponsiveness to a variety of innocuous stimuli and a more rapid decline in lung function over time.
Airway remodelling, involving proliferation and differentiation of mesenchymal cells, particularly myofibroblasts and smooth muscle cells, is generally refractory to corticosteroids and makes a major contribution to disease chronicity. Transforming growth factor-ß is a potent profibrogenic factor whose expression is increased in the asthmatic airways and is a prime candidate for the initiation and persistence of airway remodelling in asthma.
This review highlights the role of transforming growth factor-ß in the asthmatic lung, incorporating biosynthesis, signalling pathways and functional outcome. In vivo, however, it is the balance between transforming growth factor-ß and other growth factors, such as epidermal growth factor, which will determine the extent of fibrosis in the airways.
A fuller comprehension of the actions of transforming growth factor-ß, and its interaction with other signalling pathways, such as the epidermal growth factor receptor signalling cascade, may enable development of therapies that control airway remodelling where there is an unmet clinical need.
|Digital Object Identifier (DOI):||doi:10.1183/09031936.06.00130004|
|Keywords:||asthma, fibroblast, fibrosis, myofibroblast, transforming growth factor-ß|
|Subjects:||R Medicine > RB Pathology
R Medicine > RL Dermatology
Q Science > QP Physiology
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair
|Date Deposited:||25 Apr 2006|
|Last Modified:||06 Aug 2015 02:27|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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