Polymorphisms in Toll-like receptor 4 and the systemic inflammatory response syndrome
Child, N.J.A., Yang, I.A., Pulletz, M.C.K., de Courcy-Golder, K., Andrews, A.-L., Pappachan, V.J. and Holloway, J.W. (2003) Polymorphisms in Toll-like receptor 4 and the systemic inflammatory response syndrome. Biochemical Society Transactions, 31, (3), 652-653.
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Description/Abstract
The systemic inflammatory response syndrome (SIRS) is a major cause of morbidity and mortality, and is thought to be due to an over-amplification of an inflammatory response. The Toll-like receptor 4 (TLR4) Asp-299→Gly polymorphism has been shown to reduce lipopolysaccharide responsiveness. We examined whether this TLR4 polymorphism is associated with severity of SIRS. A trend was found between the minor allele and mortality in SIRS (odds ratio of 4.3; P=0.076), suggesting a role for TLR4 signalling in the severity of SIRS.
Abbreviations: SIRS, systemic inflammatory response syndrome; TLR4, Toll-like receptor 4; ICU, intensive care unit; PRR, pattern recognition receptor; LPS, lipopolysaccharide; SNP, single nucleotide polymorphism; LOS, length of stay; APACHE II, acute physiological and chronic health evaluation; LIS, lung injury score; SOFA, sequential organ failure score; PaO₂/FiO₂, partial pressure of arterial oxygen/fraction of inspired oxygen.
| Item Type: | Article |
|---|---|
| Additional Information: | Focussed meeting |
| ISSNs: | 0300-5127 (print) |
| Related URLs: | |
| Keywords: | inflammatory cytokines, lipopolysaccharide responsiveness, systemic inflammatory response syndrome (SIRS), Toll-like receptor 4 (TLR4) |
| Subjects: | R Medicine Q Science > QH Natural history > QH426 Genetics |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair University Structure - Pre August 2011 > School of Medicine > Human Genetics |
| Item ID: | 26984 |
| Date Deposited: | 25 Apr 2006 |
| Last Modified: | 31 May 2011 23:46 |
| Contributors: | Child, N.J.A. (Author) Yang, I.A. (Author) Pulletz, M.C.K. (Author) de Courcy-Golder, K. (Author) Andrews, A.-L. (Author) Pappachan, V.J. (Author) Holloway, J.W. (Author) |
| Date: | 2003 |
| Additional Information: | Focussed meeting |
| Status: | Published |
| Contact Email Address: | J.W.Holloway@soton.ac.uk |
| URI: | http://eprints.soton.ac.uk/id/eprint/26984 |
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