Microdialysis of large molecules

Clough, Geraldine F. (2005) Microdialysis of large molecules. The AAPS Journal, 7, (3), E686-E692. (doi:10.1208/aapsj070369).


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Original Publication URL: http://dx.doi.org/10.1208/aapsj070369


Microdialysis has been used in many tissues, including skin, brain, adipose tissue, muscle, kidney, and gastrointestinal tract, to recover low–molecular mass endogenous mediators, metabolites, and xenobiotics from the interstitial space. Recently, molecules of larger molecular mass, such as plasma proteins, cytokines, growth factors, and neuropeptides, have also been recovered successfully using larger-pore membranes. Microdialysis recovery of large molecules offers the opportunity to identify patterns of protein expression in a variety of tissue spaces and to evaluate clinically useful biomarkers of disease. From this may develop a better understanding of the disease process and its diagnosis and more targeted approaches to therapy.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1208/aapsj070369
ISSNs: 1522-1059 (print)
Related URLs:
Keywords: microdialysis, proteins, cytokines
Subjects: R Medicine > RM Therapeutics. Pharmacology
Q Science > QP Physiology
Divisions : University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair
ePrint ID: 26996
Accepted Date and Publication Date:
Date Deposited: 27 Apr 2006
Last Modified: 31 Mar 2016 11:50
URI: http://eprints.soton.ac.uk/id/eprint/26996

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