Peroxisome proliferator-activated receptors and their relevance to dermatology
Peroxisome proliferator-activated receptors and their relevance to dermatology
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily and are expressed in a variety of tissues including skin and cells of the immune system. They act as ligand-dependent transcription factors which heterodimerize with retinoid X receptors to allow binding to and activation of PPAR responsive genes. Through this mechanism, PPAR ligands can control a wide range of physiological processes. Based on their effects in vitro and in vivo PPAR agonists and antagonists have the potential to become important therapeutic agents for the treatment of various skin diseases. PPARs can also be activated directly by phosphorylation to have ligand-independent effects. This review will discuss the physiology of PPARs relating this to skin pathology and their role as a target for novel therapies, psoriasis, PPARs, wound healing, thiazolidinediones, transcription factors
psoriasis, PPARs, wound healing, thiazolidinediones, transcription factors
194-202
Friedmann, Peter S.
d50bac23-f3ec-4493-8fa0-fa126cbeba88
Cooper, Hywel L.
7d7f4731-171c-4607-8505-b2e07e559719
Healy, Eugene
400fc04d-f81a-474a-ae25-7ff894be0ebd
2005
Friedmann, Peter S.
d50bac23-f3ec-4493-8fa0-fa126cbeba88
Cooper, Hywel L.
7d7f4731-171c-4607-8505-b2e07e559719
Healy, Eugene
400fc04d-f81a-474a-ae25-7ff894be0ebd
Friedmann, Peter S., Cooper, Hywel L. and Healy, Eugene
(2005)
Peroxisome proliferator-activated receptors and their relevance to dermatology.
Acta Dermato-Venereologica, 85 (3), .
(doi:10.1080/00015550510030104).
Abstract
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily and are expressed in a variety of tissues including skin and cells of the immune system. They act as ligand-dependent transcription factors which heterodimerize with retinoid X receptors to allow binding to and activation of PPAR responsive genes. Through this mechanism, PPAR ligands can control a wide range of physiological processes. Based on their effects in vitro and in vivo PPAR agonists and antagonists have the potential to become important therapeutic agents for the treatment of various skin diseases. PPARs can also be activated directly by phosphorylation to have ligand-independent effects. This review will discuss the physiology of PPARs relating this to skin pathology and their role as a target for novel therapies, psoriasis, PPARs, wound healing, thiazolidinediones, transcription factors
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Published date: 2005
Keywords:
psoriasis, PPARs, wound healing, thiazolidinediones, transcription factors
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Local EPrints ID: 27061
URI: http://eprints.soton.ac.uk/id/eprint/27061
ISSN: 0001-5555
PURE UUID: 7884322c-2bd8-4ddd-ae33-7ee54ebcafa9
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Date deposited: 25 Apr 2006
Last modified: 15 Mar 2024 07:15
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Author:
Peter S. Friedmann
Author:
Hywel L. Cooper
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