ICAM-1 can play a major role in mediating P. falciparum adhesion to endothelium under flow


Gray, Carolyn, McCormick, Christopher, Turner, Gareth and Craig, Alister (2003) ICAM-1 can play a major role in mediating P. falciparum adhesion to endothelium under flow. Molecular and Biochemical Parasitology, 128, (2), 187-193. (doi:10.1016/S0166-6851(03)00075-6).

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Description/Abstract

We have investigated the importance of adhesion molecule co-operation in mediating Plasmodium falciparum adhesion to endothelial cells under flow conditions. Using three laboratory parasite lines and a patient isolate which differ in their ICAM-1 and CD36-binding avidity, we found that blockade of ICAM-1 and CD36 separately reduced IRBC adhesion by up to 95 and 50%, respectively. These results confirm previous data showing that ICAM-1 and CD36 synergize to mediate adhesion, but differ in demonstrating that without ICAM-1, binding under flow conditions is severely impaired. Thus, in this system, ICAM-1 is critical for P. falciparum adhesion to activated endothelium and once bound, synergy with CD36 mediates the majority (≥98%) of adhesion.

Item Type: Article
ISSNs: 0166-6851 (print)
Related URLs:
Keywords: icam-1, cd36, plasmodium falciparum, adhesion, hdmec, huvec
Subjects: Q Science > QP Physiology
Q Science > QR Microbiology
Divisions: University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair
ePrint ID: 27073
Date Deposited: 27 Apr 2006
Last Modified: 27 Mar 2014 18:15
Contact Email Address: agcraig@liverpool.ac.uk
URI: http://eprints.soton.ac.uk/id/eprint/27073

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