ICAM-1 can play a major role in mediating P. falciparum adhesion to endothelium under flow
Gray, Carolyn, McCormick, Christopher, Turner, Gareth and Craig, Alister (2003) ICAM-1 can play a major role in mediating P. falciparum adhesion to endothelium under flow. Molecular and Biochemical Parasitology, 128, (2), 187-193. (doi:10.1016/S0166-6851(03)00075-6).
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We have investigated the importance of adhesion molecule co-operation in mediating Plasmodium falciparum adhesion to endothelial cells under flow conditions. Using three laboratory parasite lines and a patient isolate which differ in their ICAM-1 and CD36-binding avidity, we found that blockade of ICAM-1 and CD36 separately reduced IRBC adhesion by up to 95 and 50%, respectively. These results confirm previous data showing that ICAM-1 and CD36 synergize to mediate adhesion, but differ in demonstrating that without ICAM-1, binding under flow conditions is severely impaired. Thus, in this system, ICAM-1 is critical for P. falciparum adhesion to activated endothelium and once bound, synergy with CD36 mediates the majority (≥98%) of adhesion.
|Keywords:||icam-1, cd36, plasmodium falciparum, adhesion, hdmec, huvec|
|Subjects:||Q Science > QP Physiology
Q Science > QR Microbiology
|Divisions:||University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair
|Date Deposited:||27 Apr 2006|
|Last Modified:||27 Mar 2014 18:15|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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