ICAM-1 can play a major role in mediating P. falciparum adhesion to endothelium under flow
Gray, Carolyn, McCormick, Christopher, Turner, Gareth and Craig, Alister (2003) ICAM-1 can play a major role in mediating P. falciparum adhesion to endothelium under flow. Molecular and Biochemical Parasitology, 128, (2), 187-193. (doi:10.1016/S0166-6851(03)00075-6).
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Description/Abstract
We have investigated the importance of adhesion molecule co-operation in mediating Plasmodium falciparum adhesion to endothelial cells under flow conditions. Using three laboratory parasite lines and a patient isolate which differ in their ICAM-1 and CD36-binding avidity, we found that blockade of ICAM-1 and CD36 separately reduced IRBC adhesion by up to 95 and 50%, respectively. These results confirm previous data showing that ICAM-1 and CD36 synergize to mediate adhesion, but differ in demonstrating that without ICAM-1, binding under flow conditions is severely impaired. Thus, in this system, ICAM-1 is critical for P. falciparum adhesion to activated endothelium and once bound, synergy with CD36 mediates the majority (≥98%) of adhesion.
| Item Type: | Article |
|---|---|
| ISSNs: | 0166-6851 (print) |
| Related URLs: | |
| Keywords: | icam-1, cd36, plasmodium falciparum, adhesion, hdmec, huvec |
| Subjects: | Q Science > QP Physiology Q Science > QR Microbiology |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair |
| Item ID: | 27073 |
| Date Deposited: | 27 Apr 2006 |
| Last Modified: | 01 Jun 2011 11:22 |
| Contributors: | Gray, Carolyn (Author) McCormick, Christopher (Author) Turner, Gareth (Author) Craig, Alister (Author) |
| Date: | 2003 |
| Status: | Published |
| Contact Email Address: | agcraig@liverpool.ac.uk |
| URI: | http://eprints.soton.ac.uk/id/eprint/27073 |
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